Effects of morphine on associative memory and locomotor activity in the honeybee (Apis mellifera)

	Effects of morphine on associative memory and locomotor activity in the honeybee (Apis mellifera)
	Fu Y 1; Chen YM 2; Wang JH[*]2; Yao T 2; Li P 1; Ma YY 2
刊名	NEUROSCIENCE BULLETIN
	2013
卷号	29 期号:3 页码:270-278
关键词	morphine memory locomotor activity honeybee
通讯作者	wjh16@hotmail.com
合作状况	其它
英文摘要	Morphine can modulate the processes underlying memory in vertebrates. However, studies have shown various modulations by morphine: positive, negative and even neutral. The honeybee is a potential platform for evaluating the effects of drugs, especially addictive drugs, on the nervous system. However, the involvement of morphine in learning and memory in insects or other invertebrates is poorly understood. The current work evaluated whether morphine affects memory acquisition, consolidation and retrieval in honeybees, using the proboscis extension response (PER) paradigm. We demonstrated that morphine treatment (5 mu g/bee) before training decreased the percentage of correct PERs and the response latency related to aversive rather than rewarding odors when tested after 1 or 24 h. Morphine treatment after training also caused a decrease in this latency when tested after 24 h. Meanwhile, morphine treatment reduced the ambulation distance when tested after 30 min. Our findings suggest that morphine impairs the acquisition of short- and long-term associative memory and slightly disrupts the consolidation of long-term memory in honeybees. These negative effects cannot be explained by reduced locomotion but by impaired memory associated with aversion.
收录类别	SCI
资助信息	This work was supported by grants from the Training Program for Young Backbone Teachers of Yunnan University, the Research Foundation of Yunnan University (2011YB22), the Natural Science Foundation of Yunnan Province, China (2011FZ012), the Special Fund of the “211” Third Phase Project of Yunnan University (21134018), a National Project (2007ZDGGKVST003), a Provincial National Project (2008CA012-5), National Basic Research Development Program (973 program) of China (2012CB825500, 2011CB70780), National Natural Science Foundation of China (31271168), and "Strategic Priority Research Program" of the Chinese Acedemy of Sciences, China (XD B02020500). We thank Jing He, Ping Jiang, Chang Liu, Yuhua Zhang, Jinrun Dong, Jiagui Qu and Tao Zeng for assistance with the experiments.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9277]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_神经系统编码
作者单位	1.Biomedical Engineering laboratory, Information School, Yunnan University, Kunming 650091, China 2.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Fu Y,Chen YM,Wang JH[*],et al. Effects of morphine on associative memory and locomotor activity in the honeybee (Apis mellifera)[J]. NEUROSCIENCE BULLETIN,2013,29(3):270-278.
APA	Fu Y,Chen YM,Wang JH[*],Yao T,Li P,&Ma YY.(2013).Effects of morphine on associative memory and locomotor activity in the honeybee (Apis mellifera).NEUROSCIENCE BULLETIN,29(3),270-278.
MLA	Fu Y,et al."Effects of morphine on associative memory and locomotor activity in the honeybee (Apis mellifera)".NEUROSCIENCE BULLETIN 29.3(2013):270-278.