Effects of Chronic Morphine Treatment on an Odor Conditioning Paradigm, Locomotor Activity and Sucrose Responsiveness in Honeybees (Apis mellifera) | |
Chen YM[*]1; Fu Y2,5; Yang HB1; Yao T3; Ma YY3,4; Wang JH[*]3,6 | |
刊名 | JOURNAL OF INSECT BEHAVIOR
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2014 | |
卷号 | 27期号:6页码:791-803 |
关键词 | Honeybee chronic morphine proboscis extension response memory |
通讯作者 | chyanm2@126.com ; wjh16@hotmail.com |
合作状况 | 其它 |
英文摘要 | Honeybee is a widely used insect model for learning and memory research. Recently, it has become a potentially good subject for evaluating the effects of addictive drugs on the nervous systems. Our previous study has found that acute morphine injection affected associative memory and locomotor activity in honeybees. In the current study, the effect of chronic morphine treatment and its cessation in honeybees were assessed. The results demonstrated that 1) chronic morphine (0.01, 0.1 and 1 mg/ml) treatment for 7 days severely diminished associative memory in honeybees; 2) 1 mg/ml morphine consumption for 5, 7 and 10 but not 3 days impaired the olfactory memory; 3) Bees withdrawn from morphine for 1 day but not 3 days showed amnesia in the PER conditioning. We also found that bees displayed hyperactivity and tolerance in response to chronic morphine administration. In addition, morphine dose-dependently altered the sucrose responsiveness of bees. The data indicated that chronic morphine has sensory-motor effects and may impair learning and/or memory in honeybees, which were comparative to that in vertebrates. |
收录类别 | SCI |
资助信息 | This study was supported by 973 program (2012CB825500, 2011CB707800), National Science Foundation of China (NSFC 31271168, 91132307) and the Research Foundation of Kunming University of Science and Technology (KKSY201360114). |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/9252] ![]() |
专题 | 昆明动物研究所_神经系统编码 昆明动物研究所_认知障碍病理学 |
作者单位 | 1.Medical Faculty, Kunming University of Science and Technology, #727 South Jingming Road, Kunming, Yunnan 650550, China 2.Biomedical Engineering laboratory, Information School, Yunnan University, Kunming, Yunnan 650091, China 3.Laboratory of Primate Model for Brain Disease, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 4.Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650223, China 5.Department of Psychiatry and Biobehavioral Sciences and Neurobiology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90025, USA 6.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, #32 Jiao Chang Dong Lu, Kunming, Yunnan 650223, China |
推荐引用方式 GB/T 7714 | Chen YM[*],Fu Y,Yang HB,et al. Effects of Chronic Morphine Treatment on an Odor Conditioning Paradigm, Locomotor Activity and Sucrose Responsiveness in Honeybees (Apis mellifera)[J]. JOURNAL OF INSECT BEHAVIOR,2014,27(6):791-803. |
APA | Chen YM[*],Fu Y,Yang HB,Yao T,Ma YY,&Wang JH[*].(2014).Effects of Chronic Morphine Treatment on an Odor Conditioning Paradigm, Locomotor Activity and Sucrose Responsiveness in Honeybees (Apis mellifera).JOURNAL OF INSECT BEHAVIOR,27(6),791-803. |
MLA | Chen YM[*],et al."Effects of Chronic Morphine Treatment on an Odor Conditioning Paradigm, Locomotor Activity and Sucrose Responsiveness in Honeybees (Apis mellifera)".JOURNAL OF INSECT BEHAVIOR 27.6(2014):791-803. |
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