Blockage of glucocorticoid receptors during memory acquisition,retrieval and reconsolidation prevents the expression of morphineinduced conditioned place preferences in mice

	Blockage of glucocorticoid receptors during memory acquisition,retrieval and reconsolidation prevents the expression of morphineinduced conditioned place preferences in mice
	Fan YD 1,5; Niu HC 2; Huma T 2,3; Li L 4; Wang GM 4; Xu LQ 4; Ren H 4; Ma YY[]2; Yu HL[]5
刊名	Zoological research
	2013
卷号	34 期号:E1 页码:E26-34
关键词	Addiction Conditioned place preference RU38486 Glucocorticoid receptor Retrieval Reconsolidation Reward memory
通讯作者	yuanma0716@vip.sina.com ; yuhl308@126.com
合作状况	其它
英文摘要	Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference (CPP). Glucocorticoid receptor (GRs) activation in different regions of the brain affects reward-based reinforcement and memory processing. A wide array of studies have demonstrated that blockage of GRs in some brain areas can have an effect on reward-related memory; however, to date there have been no systematic studies about the involvement of glucocorticoids (GCs) in morphine-related reward memory. Here, we used the GR antagonist RU38486 to investigate how GRs blockage affects the sensitization and CPP behavior during different phases of reward memory included acquisition, retrieval and reconsolidation. Interestingly, our results showed RU38486 has the ability to impair the acquisition, retrieval and reconsolidation of reward-based memory in CPP and sensitization behavior. But RU38486 by itself cannot induce CPP or conditioned place aversion (CPA) behavior. Our data provide a much more complete picture of the potential effects that glucocorticoids have on the reward memory of different phases and inhibit the sensitization behavior.
收录类别	其他
语种	英语
公开日期	2014-06-03
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7860]
专题	昆明动物研究所_认知障碍病理学
作者单位	1.Department of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Province Tumor Hospital), Kunming 650118, China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Laboratory of Reproductive Neuroendocrinology, Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan 4.Kunming General Hospital of Chengdu Military Region, People's Liberation Army, Kunming 650032, China 5.Minimally Invasive Neurosurgery Department, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
推荐引用方式 GB/T 7714	Fan YD,Niu HC,Huma T,et al. Blockage of glucocorticoid receptors during memory acquisition,retrieval and reconsolidation prevents the expression of morphineinduced conditioned place preferences in mice[J]. Zoological research,2013,34(E1):E26-34.
APA	Fan YD.,Niu HC.,Huma T.,Li L.,Wang GM.,...&Yu HL[*].(2013).Blockage of glucocorticoid receptors during memory acquisition,retrieval and reconsolidation prevents the expression of morphineinduced conditioned place preferences in mice.Zoological research,34(E1),E26-34.
MLA	Fan YD,et al."Blockage of glucocorticoid receptors during memory acquisition,retrieval and reconsolidation prevents the expression of morphineinduced conditioned place preferences in mice".Zoological research 34.E1(2013):E26-34.