Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice

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	Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice
	Wang YF 1,2; Wu J 1; Zhu B 1; Li CC 1; Cai JX[*]1
刊名	STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
	2012
卷号	15 期号:2 页码:237-242
关键词	Dopamine D1 receptor emotional memory mice stress SCH23390
通讯作者	caijx@mail.kiz.ac.cn
英文摘要	It is established that stress impairs spatial learning and memory via the hypothalamus-pituitary-adrenal axis response. Dopamine D1 receptors were also shown to be responsible for a stress-induced deficit of working memory. However, whether stress affects the subsequent emotional learning and memory is not elucidated yet. Here, we employed the well-established one-trial step-through task to study the effect of an acute psychological stress (induced by tail hanging for 5, 10, or 20 min) on emotional learning and memory, and the possible mechanisms as well. We demonstrated that tail hanging induced an obvious stress response. Either an acute tail-hanging stress or a single dose of intraperitoneally injected dopamine D1 receptor antagonist (SCH23390) significantly decreased the step-through latency in the one-trial step-through task. However, SCH23390 prevented the acute tail-hanging stress-induced decrease in the step-through latency. In addition, the effects of tail-hanging stress and/or SCH23390 on the changes in step-through latency were not through non-memory factors such as nociceptive perception and motor function. Our data indicate that the hyperactivation of dopamine D1 receptors mediated the stress-induced deficit of emotional learning and memory. This study may have clinical significance given that psychological stress is considered to play a role in susceptibility to some mental diseases such as depression and post-traumatic stress disorder.
收录类别	SCI
资助信息	This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai.
语种	英语
WOS记录号	WOS:000299504300012
公开日期	2012-04-05
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/6909]
专题	昆明动物研究所_发育生物学昆明动物研究所_其他
作者单位	1.Section of Brain and Behavior, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, PR China 2.Graduate School of the Chinese Academy of Sciences, Beijing, PR China
推荐引用方式 GB/T 7714	Wang YF,Wu J,Zhu B,et al. Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice[J]. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,2012,15(2):237-242.
APA	Wang YF,Wu J,Zhu B,Li CC,&Cai JX[*].(2012).Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice.STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,15(2),237-242.
MLA	Wang YF,et al."Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice".STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 15.2(2012):237-242.