Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 神经系统编码

	Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey
	Wang JH 1,2,3; Zhang B 1,2,3; Meng ZQ 1,2,3; Sun NL 1,2,3; Ma MX 4; Zhang HX 1,2; Tang XD 5; Sanford LD 5; Wilson FAW 1,2; Hu XT[*]1,2
刊名	DEVELOPMENTAL NEUROBIOLOGY
	2007
卷号	67 期号:13 页码:1731-1741
关键词	maze MK-801 rhesus monkey spatial memory working memory
ISSN号	1932-8451
通讯作者	xthu@mail.kiz.ac.cn ; yuanma0716@vip.sina.com
英文摘要	Monkeys have strong abilities to remember the visual properties of potential food sources for survival in the nature. The present study demonstrated the first observations of rhesus monkeys learning to solve complex spatial mazes in which routes were guided by visual cues. Three monkeys were trained in a maze (6 m x 6 m) included of four different mazes. We recorded the cue and cup errors, latencies, and pathway for each trial. The data showed that monkeys learned the target place after three days in the first maze and spent a shorter time in learning the following mazes. The maze was an efficient method to measure the ability and proceeding of spatial memory in monkeys. Moreover, working memory can also be tested by using the maze. MK-801 at 0.02 mg/kg but not at 0.005 mg/kg impaired monkeys' retrieval of spatial memory after they learned all four mazes. The present maze may provide an efficient method to help bridging the gap in cognition between nonhuman primates and humans, and in particular to gain insight into human cognitive function and dysfunction.
收录类别	SCI
资助信息	National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki.
原文出处	2007671731.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5515]
专题	昆明动物研究所_神经系统编码昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_认知障碍病理学昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 2.Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China 3.Graduate School of Chinese Academy of Sciences, Beijing, People’s Republic of China 4.Department of Psychology, Jilin University, Chang Chun, People’s Republic of China 5.Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia, U.S.A 6.Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland and Medical School, University of Tampere, Tampere, Finland
推荐引用方式 GB/T 7714	Wang JH,Zhang B,Meng ZQ,et al. Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey[J]. DEVELOPMENTAL NEUROBIOLOGY,2007,67(13):1731-1741.
APA	Wang JH.,Zhang B.,Meng ZQ.,Sun NL.,Ma MX.,...&Ma YY[*].(2007).Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey.DEVELOPMENTAL NEUROBIOLOGY,67(13),1731-1741.
MLA	Wang JH,et al."Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey".DEVELOPMENTAL NEUROBIOLOGY 67.13(2007):1731-1741.