Aging Affects the Neural Representation of Speed in Macaque Area MT

	Aging Affects the Neural Representation of Speed in Macaque Area MT
	Yang Y 1; Zhang J 2; Liang Z 1; Li GX 1; Wang YC 1,3; Ma YY 2; Zhou YF[*]1,4; Leventhal AG 1,3
刊名	CEREBRAL CORTEX
	2009
卷号	19 期号:9 页码:1957-1967
关键词	aging area MT degradation inhibition macaque speed
ISSN号	1047-3211
通讯作者	zhouy@ustc.edu.cn
合作状况	其它
英文摘要	Human perception of speed declines with age. Much of the decline is probably mediated by changes in the middle temporal (MT) area, an extrastriate area whose neural activity is linked to the perception of speed. In the present study, we used random-dot patterns to study the effects of aging on speed-tuning curves in cortical area MT of macaque visual cortex. Our results provide evidence for a significant degradation of speed selectivity in MT. Cells in old animals preferred lower speeds than did those in young animals. Response modulation and discriminative capacity for speed in old monkeys were also significantly weaker than those in young ones. Concurrently, MT cells in old monkeys showed increased baseline responses, peak responses and response variability, and these changes were accompanied by decreased signal-to-noise ratios. We also found that speed discrimination thresholds in old animals were higher than in young ones. The foregoing neural changes may mediate the declines in visual motion perception that occur during senescence.
学科主题	Neurosciences
收录类别	SCI
资助信息	National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L.
原文出处	20091991957.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5493]
专题	昆明动物研究所_认知障碍病理学
作者单位	1.Vision Research Laboratory, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China 2.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan 650223, China 3.Department of Neurobiology and Anatomy, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA 4.State key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China
推荐引用方式 GB/T 7714	Yang Y,Zhang J,Liang Z,et al. Aging Affects the Neural Representation of Speed in Macaque Area MT[J]. CEREBRAL CORTEX,2009,19(9):1957-1967.
APA	Yang Y.,Zhang J.,Liang Z.,Li GX.,Wang YC.,...&Leventhal AG.(2009).Aging Affects the Neural Representation of Speed in Macaque Area MT.CEREBRAL CORTEX,19(9),1957-1967.
MLA	Yang Y,et al."Aging Affects the Neural Representation of Speed in Macaque Area MT".CEREBRAL CORTEX 19.9(2009):1957-1967.