Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice

	Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice
	He J 1,2; Chen YM 1,2; Wang JH 1; Ma YY[*]1
刊名	动物学研究
	2008
卷号	29 期号:6 页码:613-620
关键词	Retrieval Morphine Scopolamine Atropine Y-maze
其他题名	吗啡和胆碱能拮抗剂联合给药对小鼠Y迷宫空间记忆提取及活动性的影响
通讯作者	yuanma0716@vip.sina.com
合作状况	其它
中文摘要	吗啡和胆碱能系统的相互作用已在多项研究中提到,本实验想查明吗啡是否能和胆碱能拮抗剂、东莨菪碱以及阿托品共同作用对小鼠的Y迷宫空间识别记忆提取产生影响.采用测试前腹腔给药的方法,选用3种剂量的吗啡(5、1.5、0.5mg/kg),两种剂量的东莨菪碱(1、0.1mg/kg),以及两种剂量的阿托品(0.5、0.1mg/kg),剂量由高到低相配对作为联合给药的手段.其结果表明:1)0.5mg/kg低剂量吗啡与0.1 mg/kg低剂量的东莨菪碱,或与0.1 mg/kg低剂最的阿托品联合给药的小鼠,在记忆提取测试中, 空间探查行为(各臂停留时间百分比)对新异臂没有偏好,而新奇探索行为(各臂访问次数百分比)仍保持了对新异臂的偏好,而相应剂最药物单独给药的小鼠记忆提取均没有被损害;2)吗啡能和东莨菪碱相互作用使小鼠的活动性显著增强.暗示吗啡和胆碱能拮抗剂对小鼠空间记忆提取的破坏存在一定程度的相互作用.
英文摘要	Abstract：The interaction of morphine and cholinergie system was shown in previous studies．In the present smd％ we investigated whether morphine would interact with the cholinergic antagonists，scopolamine and atropine in a Y-maze spatial recognition memory．Pre—test treatments of morphine(5，1．5，0．5 mg／kg)，scopolamine(1，0．1 mg／kg)，atropine(0．5， 0．1 mg／kg)were used in the experiments，relatively high or low doses were paired respectively as co—administration measures．The results showed that CO—administration of morphine 0．5 mg／kg+scopolamine 0．1 mg／l【g and morphine 0．5 mg／kg+atropine 0．1 mg／kg disturbed the inspective exploratory behavior(percent of arm duration)but not the inquisitive behavior(percent of arm visits)of the spatial memory retrieval，while the drugs didn’t cause amnesia when single administered of the concemed low doses．Distinct interaction was found between scopolamine and morphine on increasing locomotor activity．
收录类别	其他
资助信息	National Natural Science Foundation of China (30770700; 30470553)
语种	英语
公开日期	2010-08-05
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/955]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_神经系统编码
作者单位	1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology,the Chinese Academy of Sciences, Kunming Yunnan 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	He J,Chen YM,Wang JH,et al. Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice[J]. 动物学研究,2008,29(6):613-620.
APA	He J,Chen YM,Wang JH,&Ma YY[*].(2008).Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice.动物学研究,29(6),613-620.
MLA	He J,et al."Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice".动物学研究 29.6(2008):613-620.