Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis

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	Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis
	Tang NLS[*]1,5,7; Fan HPY 1; Tam CM 2; Blackwell J 5; Chan CY 6; Chang KC 2; Ching JKL 1; Kong KPS 1; Yew WW 3; Kam KM 2
刊名	CLINICA CHIMICA ACTA
	2009
卷号	406 期号:1-2 页码:98-102
关键词	Tuberculosis Genetic susceptibility IP-10 CXCL-10
通讯作者	nelsontang@cuhk.edu.hk
合作状况	其它
英文摘要	Background: Previous studies showed that activation of CXCL-10 and other chemokines were prominent in many infectious diseases. These chemokines are components of innate immune response to respiratory tract pathogens. We examined the promoter variants of CXCL-10 and their role in predisposition to tuberculosis (TB). Methods: The promoter 1.8 kb of CXCL-10 was sequenced in 24 healthy Chinese individuals to identify genetic polymorphisms. Three tagging SNPs in CXCL-10 promoter (-1447A>G, -872G>A, -135G>A) were selected, and genotyping were performed in 240 TB patients and 176 healthy Chinese subjects. Disease associations were examined by chi(2) and Fisher exact test. Results: A promoter SNP (-1356>A) with minor allele frequency of 0.1 showed a moderate association with TB both in genotype analysis (p = 0.01) and allelic analysis (p = 0.03); other tagging SNPs (-1447A>G, -872G>A) were not associated with TB. The odd ratio of the protective allele -1356>A was 0.51(C.I 0.29 - 0.91) for homozygotes and heterozygotes carriers of the A allele. Conclusion: A new potential protective SNP (-1356>A) for TB is identified in the promoter of chemokine gene, CXCL-10. Interestingly, the exact same allele has been shown to enhance IP-10 transactivation and susceptibility to Hepatitis B virus infection in a recent publication. This SNP, located at 14 by upstream of a NF-kB binding site, might also account for the susceptibility to TB. Our results expanded the clinical significance of this SNP in CXCL-10 promoter.
收录类别	SCI
资助信息	The work is supported by the Research Fund for the Control of Infectious Disease (RFCID:CUHK-BS-009) from the Health, Welfare and Food Bureau of the Hong Kong SAR Government.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10477]
专题	昆明动物研究所_其他
作者单位	1.Department of Chemical Pathology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, China 2.Department of Health, Hong Kong SAR Government, Hong Kong, China 3.Tuberculosis and Chest Unit, Grantham Hospital, Hospital Authority, Hong Kong, China 4.Joint Laboratory of Bioresources and Molecular Research in Common Diseases, The Chinese University of Hong Kong and Kunming Institute of Zoology, China 5.Cambridge Institute of Medical Research, University of Cambridge, UK 6.Department of Microbiology, Chinese University of Hong Kong, Shatin, Hong Kong, China 7.Laboratory of Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
推荐引用方式 GB/T 7714	Tang NLS[*],Fan HPY,Tam CM,et al. Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis[J]. CLINICA CHIMICA ACTA,2009,406(1-2):98-102.
APA	Tang NLS[*].,Fan HPY.,Tam CM.,Blackwell J.,Chan CY.,...&Leung CC.(2009).Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis.CLINICA CHIMICA ACTA,406(1-2),98-102.
MLA	Tang NLS[*],et al."Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis".CLINICA CHIMICA ACTA 406.1-2(2009):98-102.