Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 离子通道药物研发中心

	Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear
	Zhou FJ 1,5; Nian Y 3; Yan YM 1,2,3; Gong Y 3; Luo Q 1,2; Zhang Y 1; Hou B 1; Zuo ZL 1; Wang SM 5; Jiang HH 3
刊名	ORGANIC LETTERS
	2015
卷号	17 期号:12 页码:3082-3085
通讯作者	jy160@columbia.edu ; yxcheng@mail.kib.ac.cn
合作状况	其它
英文摘要	T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (+/-)-6 significantly inhibited Ca(v)3.1 TTCC and showed noticeable selectivity against Ca(v)1.2, Ca(v)2.1, Ca(v)2.2, and K(v)11.1 (hERG) channels.
收录类别	SCI
资助信息	This study was supported by the NSFC-Joint Foundation of Yunnan Province (U1202222 to Y.-X.C.), the National Natural Science Foundation of China (21472199 to Y.-X.C. and 31370821toJ.Y.),theTopTalentsProgramofYunnanProvince (2011HA012 to J.Y.), and High-Level Overseas Talents of Yunnan Province (J.Y.).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9332]
专题	昆明动物研究所_离子通道药物研发中心昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P.R. China 2.University of Chinese Academy of Sciences, Beijing 100049, P.R. China 3.Key Laboratory of Animal Models and Human Disease Mechanisms, and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R. China 4.Department of Biological Sciences, Columbia University, New York, New York 10027, United States 5.Guangdong Pharmaceutical University, Guangzhou 510006, P.R. China
推荐引用方式 GB/T 7714	Zhou FJ,Nian Y,Yan YM,et al. Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear[J]. ORGANIC LETTERS,2015,17(12):3082-3085.
APA	Zhou FJ.,Nian Y.,Yan YM.,Gong Y.,Luo Q.,...&Cheng YX[*].(2015).Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.ORGANIC LETTERS,17(12),3082-3085.
MLA	Zhou FJ,et al."Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear".ORGANIC LETTERS 17.12(2015):3082-3085.