RGK regulation of voltage-gated calcium channels

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 离子通道药物研发中心

	RGK regulation of voltage-gated calcium channels
	Buraei Z[]1; Lumen E 1; Kaur S 1; Yang J[]2,3
刊名	SCIENCE CHINA-LIFE SCIENCES
	2015
卷号	58 期号:1 页码:28-38
关键词	calcium channel modulation trafficking cardiac physiology neurobiology beta subunit
通讯作者	zburaei@pace.edu ; jianyang@mail.kiz.ac.cn
合作状况	其它
英文摘要	Voltage-gated calcium channels (VGCCs) play critical roles in cardiac and skeletal muscle contractions, hormone and neurotransmitter release, as well as slower processes such as cell proliferation, differentiation, migration and death. Mutations in VGCCs lead to numerous cardiac, muscle and neurological disease, and their physiological function is tightly regulated by kinases, phosphatases, G-proteins, calmodulin and many other proteins. Fifteen years ago, RGK proteins were discovered as the most potent endogenous regulators of VGCCs. They are a family of monomeric GTPases (Rad, Rem, Rem2, and Gem/Kir), in the superfamily of Ras GTPases, and they have two known functions: regulation of cytoskeletal dynamics including dendritic arborization and inhibition of VGCCs. Here we review the mechanisms and molecular determinants of RGK-mediated VGCC inhibition, the physiological impact of this inhibition, and recent evidence linking the two known RGK functions.
收录类别	SCI
资助信息	This work was supported by the Dyson College 2014 Faculty Summer Research Grant Program (Zafir Buraei), Dyson College 2014 Summer Undergraduate Student-Faculty Research Award (Zafir Buraei and Su- khjinder Kaur), the National Key Basic Research Program of China (2014CB910301 to Yang Jian), the Top Talents Program of Yunnan Prov- ince, China (Yang Jian), and the US National Institutes of Health (NS053494 to Yang Jian).
语种	英语
公开日期	2015-02-13
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8258]
专题	昆明动物研究所_离子通道药物研发中心昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Department of Biology, Pace University, New York, NY 10038, USA 2.Ion Channel Research and Drug Development Center, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Department of Biological Sciences, Columbia University, New York, NY 10027, USA
推荐引用方式 GB/T 7714	Buraei Z[*],Lumen E,Kaur S,et al. RGK regulation of voltage-gated calcium channels[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(1):28-38.
APA	Buraei Z[],Lumen E,Kaur S,&Yang J[].(2015).RGK regulation of voltage-gated calcium channels.SCIENCE CHINA-LIFE SCIENCES,58(1),28-38.
MLA	Buraei Z[*],et al."RGK regulation of voltage-gated calcium channels".SCIENCE CHINA-LIFE SCIENCES 58.1(2015):28-38.