Smallest bitter taste receptor (T2Rs) gene repertoire in carnivores

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	Smallest bitter taste receptor (T2Rs) gene repertoire in carnivores
	Hu LL 1,2; Shi P[*]1
刊名	Zoological Research
	2013
卷号	34 期号:E3 页码:E75−E81
关键词	T2R Bitter taste Carnivores Duplication
通讯作者	ship@mail.kiz.ac.cn.
合作状况	其它
英文摘要	Bitter taste reception is presumably associated with dietary selection, preventing animals from ingesting potentially harmful compounds. Accordingly, carnivores, who encounter these toxic substances less often, should have fewer genes associated with bitter taste reception compared with herbivores and omnivores. To investigate the genetic basis of bitter taste reception, we confirmed bitter taste receptor (T2R) genes previously found in the genome sequences of two herbivores (cow and horse), two omnivores (mouse and rat) and one carnivore (dog). We also identified, for the first time, the T2R repertoire from the genome of other four carnivore species (ferret, giant panda, polar bear and cat) and detected 17-20 bitter receptor genes from the five carnivore genomes, including 12-16 intact genes, 0-1 partial but putatively functional genes, and 3-8 pseudogenes. Both the intact T2R genes and the total T2R gene number among carnivores were the smallest among the tested species, supporting earlier speculations that carnivores have fewer T2R genes, herbivores an intermediate number, and omnivores the largest T2R gene repertoire. To further explain the genetic basis for this disparity, we constructed a phylogenetic tree, which showed most of the T2R genes from the five carnivores were one-to-one orthologs across the tree, suggesting that carnivore T2Rs were conserved among mammals. Similarly, the small carnivore T2R family size was likely due to rare duplication events. Collectively, these results strengthen arguments for the connection between T2R gene family size, diet and habit.
收录类别	其他
资助信息	This work was supported by the Key Project (30930015) and General Project (31271329) from National Natural Science Foundation of China
语种	英语
公开日期	2014-06-03
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7848]
专题	昆明动物研究所_进化与功能基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	Hu LL,Shi P[*]. Smallest bitter taste receptor (T2Rs) gene repertoire in carnivores[J]. Zoological Research,2013,34(E3):E75−E81.
APA	Hu LL,&Shi P[*].(2013).Smallest bitter taste receptor (T2Rs) gene repertoire in carnivores.Zoological Research,34(E3),E75−E81.
MLA	Hu LL,et al."Smallest bitter taste receptor (T2Rs) gene repertoire in carnivores".Zoological Research 34.E3(2013):E75−E81.