Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 进化与功能基因组学

	Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates
	Zhang Z 1,2,3; Liu J 1; Li M 1; Yang H[]2; Zhang CY[]1,3
刊名	PLOS ONE
	2012
卷号	7 期号:11 页码:10
通讯作者	yanghui@mail.kiz.ac.cn ; zhangcy1999@hotmail.com
合作状况	其它
英文摘要	Vertebrate interferon-induced transmembrane (IFITM) genes have been demonstrated to have extensive and diverse functions, playing important roles in the evolution of vertebrates. Despite observance of their functionality, the evolutionary dynamics of this gene family are complex and currently unknown. Here, we performed detailed evolutionary analyses to unravel the evolutionary history of the vertebrate IFITM family. A total of 174 IFITM orthologous genes and 112 pseudogenes were identified from 27 vertebrate genome sequences. The vertebrate IFITM family can be divided into immunity-related IFITM (IR-IFITM), IFITM5 and IFITM10 sub-families in phylogeny, implying origins from three different progenitors. In general, vertebrate IFITM genes are located in two loci, one containing the IFITM10 gene, and the other locus containing IFITM5 and various numbers of IR-IFITM genes. Conservation of evolutionary synteny was observed in these IFITM genes. Significant functional divergence was detected among the three IFITM sub-families. No gene duplication or positive selection was found in IFITM5 sub-family, implying the functional conservation of IFITM5 in vertebrate evolution, which is involved in bone formation. No IFITM5 locus was identified in the marmoset genome, suggesting a potential association with the tiny size of this monkey. The IFITM10 sub-family was divided into two groups: aquatic and terrestrial types. Functional divergence was detected between the two groups, and five IFITM10-like genes from frog were dispersed into the two groups. Both gene duplication and positive selection were observed in aquatic vertebrate IFITM10-like genes, indicating that IFITM10 might be associated with the adaptation to aquatic environments. A large number of lineage-and species-specific gene duplications were observed in IR-IFITM sub-family and positive selection was detected in IR-IFITM of primates and rodents. Because primates have experienced a long history of viral infection, such rapid expansion and positive selection suggests that the evolution of primate IR-IFITM genes is associated with broad-spectrum antiviral activity.
收录类别	SCI
资助信息	This work was supported by the Open Project of State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, CAS (GREKF10-08), the ‘‘Top-notch personnel’’ Project of Jiangsu University to CZ, and a grant from National Natural Science Foundation of China (No. 30900793) to HY.
语种	英语
WOS记录号	WOS:000311272300036
公开日期	2013-04-08
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7305]
专题	昆明动物研究所_进化与功能基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Institute of Life Sciences, Jiangsu University, Jiangsu, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Diagnostic center for pathogens, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
推荐引用方式 GB/T 7714	Zhang Z,Liu J,Li M,et al. Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates[J]. PLOS ONE,2012,7(11):10.
APA	Zhang Z,Liu J,Li M,Yang H[],&Zhang CY[].(2012).Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates.PLOS ONE,7(11),10.
MLA	Zhang Z,et al."Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates".PLOS ONE 7.11(2012):10.