Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study

	Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study
	Li WX 1,2; Li W 3; Zhang H 3; Zhang Q 3; Tang L 3; Wang MM 3; Huang JF 2,6,7; Liu DH[*]3; Cao JQ 4,5; Yan HY 3
刊名	JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
	2016
卷号	62 期号:4 页码:265-271
关键词	folate deficiency MTHFR gene polymorphisms alanine aminotransferase aspartate transaminase glutamyl transpeptidase
通讯作者	seansean2014@126.com
合作状况	其它
英文摘要	Alanine aminotransferase (ALT), aspartate transaminase (AST), and glutamyl transpeptidase (GGT) were three key enzymes in the hepatic metabolism. This study aimed to investigate the effect of homocysteine (Hcy) metabolism gene polymorphisms and serum Hcy and folate level on the hepatic functions in a Chinese hypertensive population. A representative sample with 480 subjects aged 28-75 was enrolled in 2005.9-2005.12 from six hospitals in different Chinese regions. Serum ALT, AST and GGT were measured by using an automatic biochemistry analyzer. Serum Hcy was measured by high-performance liquid chromatography, and serum folate was measured by chemiluminescent immunoassay. Known genotypes were detected by PCR-RFLP methods. The results showed that the MTHFR C677T mutation was related a decreased serum AST level (r=-0.11, p= 0.026), whereas the MTHFR A1298C mutation elevated serum AST level (r = 0.11, p=0.032). Furthermore, multiple regression analysis showed that folate deficiency was associated with higher serum ALT (beta(SE): 0.13 (0.06), p= 0.031) and GGT level (beta (SE): 0.18(0.07), p= 0.011). However, serum Hcy level may not affect the hepatic functions. Our data suggested that hepatic functions were affected by MTHFR gene polymorphisms and serum folate level. Further studies are needed to confirm these correlations in a larger population.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10768]
专题	昆明动物研究所_结构生物信息学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Institute of Health Sciences, Anhui University 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences 3.Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University 4.CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences 5.University of Chinese Academy of Sciences 6.KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University 7.Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan
推荐引用方式 GB/T 7714	Li WX,Li W,Zhang H,et al. Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study[J]. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY,2016,62(4):265-271.
APA	Li WX.,Li W.,Zhang H.,Zhang Q.,Tang L.,...&Sun YY.(2016).Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study.JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY,62(4),265-271.
MLA	Li WX,et al."Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study".JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 62.4(2016):265-271.