Eucaryotic DNA Methylation and Gene Mutation

	Eucaryotic DNA Methylation and Gene Mutation
	Liu CQ 1,2; Wang Y 1,2; Huang JF 1,2; Liu WB 1,2
刊名	动物学研究
	1993
卷号	14 期号:S1 页码:89-98
关键词	DNA methylation 5-methylcytosine Deamination Eucaryotic DNA Gene mutation
其他题名	真核生物DNA甲基化作用与基因突变
中文摘要	迄今为止,不少人认为5-甲基胞嘧啶的存在可能是基因突变的“热点”。然而,事实上5-甲基胞嘧啶作为一种稀有碱基,本来就是许多真核生物DNA的正常组分。它的存在也是真核生物DNA的特征之一。我们几年来所作的理论研究表明,5-甲基胞嘧啶不可能是基因突变的“热点”。由胞嘧啶甲基化成为5-甲基胞嘧啶,再经水解脱氨成为胸腺嘧啶的反应(C→m~5C→T)在正常生理条件下是不太可能发生的。在真核生物DNA中,G—C碱基对转变为A—T碱基对的反应可能是由互变异构碱基配对或其它因素引起的。更多还原
英文摘要	5-methylcytosine (m5C) as a rare base exists in eucaryotic genomes,it is a normal constituent of many eucaryotic DNA,whose existence is a character of eucaryotic DNA.In the regular physiological conditions,cytosine residue of eucaryotic DNA is methylated to be popular.Up to the present,many people consider that the m5C may be mutation hotspots by the m5C deamination leading to gene mutation.Our theoretical investigations indicated that the spontaneous mutation caused by the transition of G·C→A·T,in eukaryotic DNA,may be a result caused by the tautomer changing base pairs and may also be caused by other factor actions,however it could not be caused by the deamination of m5C.
收录类别	其他
资助信息	国家自然科学基金
语种	中文
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9895]
专题	昆明动物研究所_结构生物信息学昆明动物研究所_细胞与分子进化开放实验室
作者单位	1.Laboratory of Cellular and Molecular Evolution,Kunming Institute of Zoology,Academia Sinica,Kunming 650223,China 2.Modern Biological Center,University of Yunnan Kunming 650091,China
推荐引用方式 GB/T 7714	Liu CQ,Wang Y,Huang JF,et al. Eucaryotic DNA Methylation and Gene Mutation[J]. 动物学研究,1993,14(S1):89-98.
APA	Liu CQ,Wang Y,Huang JF,&Liu WB.(1993).Eucaryotic DNA Methylation and Gene Mutation.动物学研究,14(S1),89-98.
MLA	Liu CQ,et al."Eucaryotic DNA Methylation and Gene Mutation".动物学研究 14.S1(1993):89-98.