Pleiotropy of the de novo-originated gene MDF1

	Pleiotropy of the de novo-originated gene MDF1
	Li D 1; Yan ZH 2; Lu LN 2; Jiang HF[]2; Wang W[]1
刊名	SCIENTIFIC REPORTS
	2014
卷号	4 期号:X 页码:e7280
通讯作者	jiang_hf@tib.cas.cn ; wwang@mail.kiz.ac.cn
合作状况	其它
英文摘要	MDF1 is a young de novo-originated gene from a non-coding sequence in baker's yeast, S. cerevisiae, which can suppress mating and promote vegetative growth. Our previous experiments successfully demonstrated how Mdf1p binds to the key mating pathway determinant MAT alpha 2 to suppress mating. However, how Mdf1p promotes growth and fulfills the crosstalk between the yeast mating and growth pathways are still open questions. Thus, the adaptive significance of this new de novo gene remains speculative. Here, we show that Mdf1p shortens the lag phase of S. cerevisiae by physically interacting with SNF1, the governing factor for nonfermentable carbon source utilization, and thereby confers a selective advantage on yeasts through the rapid consumption of glucose in the early generational stage in rich medium. Therefore, MDF1 functions in two important molecular pathways, mating and fermentation, and mediates the crosstalk between reproduction and vegetative growth. Together, our results provide a comprehensive example of how a de novo-originated gene organizes new regulatory circuits and thereby confers a selective advantage on S. cerevisiae to allow exquisite adaptation to the changing environment.
收录类别	SCI
资助信息	This work was supported by funds from a 973 Program (2011CBA00805) and a Tianjin Sci-tech Support Program (11ZCKFSY08000) granted to H.J. and an NSFC key grant (No. 30930056), 973 Program funds (No. 2007CB815700) and a CAS-Max Planck Society Fellowship granted to W.W.
语种	英语
WOS记录号	WOS:000346259100008
公开日期	2015-01-19
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8224]
专题	昆明动物研究所_基因起源组昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan 650223, People’s Republic of China 2.Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences(CAS), Tianjin 300308, People’s Republic of China
推荐引用方式 GB/T 7714	Li D,Yan ZH,Lu LN,et al. Pleiotropy of the de novo-originated gene MDF1[J]. SCIENTIFIC REPORTS,2014,4(X):e7280.
APA	Li D,Yan ZH,Lu LN,Jiang HF[],&Wang W[].(2014).Pleiotropy of the de novo-originated gene MDF1.SCIENTIFIC REPORTS,4(X),e7280.
MLA	Li D,et al."Pleiotropy of the de novo-originated gene MDF1".SCIENTIFIC REPORTS 4.X(2014):e7280.