Evolution of alternative splicing in newly evolved genes of Drosophila

	Evolution of alternative splicing in newly evolved genes of Drosophila
	Zhan ZB 1,2; Ren JA 1,2; Zhang Y 1; Zhao RP 1; Yang SA 1; Wang W[*]1
刊名	GENE
	2011
卷号	470 期号:1-2 页码:1-6
关键词	New genes Alternative splicing Gene duplication Retroposition Expression pattern
通讯作者	wwang@mail.kiz.ac.cn
合作状况	其它
英文摘要	New gene origination is a fundamental process underlying evolution of biological diversity Although new genes usually evolve rapidly in sequences structure and expression the evolutionary pattern of alternative splicing (AS) in new genes and the molecular mechanisms involved in this alternation remain to be explored Here we used the new genes identified in the Drosophila melanogaster lineage to study alternation of AS and the possible functional consequences of these genes We found that new genes tended to exhibit low degree of AS though a few new genes were alternatively spliced Interestingly loss of introns in retroposed new genes can only account for one third of the low-level AS in new genes while partial gene duplication without AS exons and mutations in the duplicated AS exons/introns together have resulted in two-third AS losses in new genes indicating that reducing the degree of AS is a general trend in all categories of new genes Further investigations on tissue expression patterns of these new genes showed that those with AS alternation had a relatively lower expression level were expressed in fewer tissues and tended to be more likely expressed in testis than their parental genes All these observations imply that these new genes may have gained diverged structures and expression patterns from their parental genes after AS alternation
收录类别	SCI
资助信息	This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283).
语种	英语
公开日期	2011-01-29
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6566]
专题	昆明动物研究所_基因起源组昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan 650223, China 2.Graduate School of Chinese Academy Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Zhan ZB,Ren JA,Zhang Y,et al. Evolution of alternative splicing in newly evolved genes of Drosophila[J]. GENE,2011,470(1-2):1-6.
APA	Zhan ZB,Ren JA,Zhang Y,Zhao RP,Yang SA,&Wang W[*].(2011).Evolution of alternative splicing in newly evolved genes of Drosophila.GENE,470(1-2),1-6.
MLA	Zhan ZB,et al."Evolution of alternative splicing in newly evolved genes of Drosophila".GENE 470.1-2(2011):1-6.