Analysis of mitochondrial DNA polymorphisms in Guangdong Han Chinese

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	Analysis of mitochondrial DNA polymorphisms in Guangdong Han Chinese
	Chen F 1; Wang SY[]1; Liu YH 2; Kong QP[]3; Zhang RZ 1; Hu YH 1; Gao GF 1
刊名	FORENSIC SCIENCE INTERNATIONAL-GENETICS
	2008
卷号	2 期号:2 页码:150-153
关键词	Han Chinese Guangdong mtDNA Phylogeny Haplogroup
通讯作者	shayanw@yahoo.com ; kongqp@yahoo.com.cn
合作状况	其它
英文摘要	Previous investigations on Chinese mitochondrial DNA (mtDNA) variation revealed that the matrilineal gene pool of southern Han Chinese is rather complex, with much higher genetic diversity and more basal/ancient lineages than the northern Hans. The extreme case is Guangdong Han populations, among which pronounced (matrilineal) differentiation has been observed, indicative of complex demography of the region. To get more insights into the maternal makeup of southern Han Chinese, mtDNA variation of a total of 106 individuals sampled from Dongguan, Guangdong Province, China, was analyzed in this study. With the aid of the information from control-region hypervariablc segments I and II (HVS-I and -II) as well as some necessary coding-region segments, the phylogenetic status of all mtDNAs under examination were determined according to the reconstructed East Asian mtDNA tree. In this way, the mtDNAs have been classified into various haplogroups or sub-haplogroups. The southern-prevalent haplogroups, Such as R9 (20.8%) B (17.9%), M7b (14.2%), show relatively high distribution frequencies in Dongguan Hans; whereas the frequencies of Northern-prevalent haplogroups (with the exception of D) are quite low: C (1.9%), G2 (1.9%) and Z (1.9%), indicating the southern-origin of Dongguan Hans.
收录类别	SCI
资助信息	This project was supported by Natural Science Foundation (No. 04006969) of Guangdong Province and Science Founda- tion of Shenzhen City.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10510]
专题	昆明动物研究所_分子人类学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen 518020, China 2.Sun Yat-sen University Tungwah Dongguan Tungwah Hospital, Dongguan 523110, China 3.State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Chen F,Wang SY[*],Liu YH,et al. Analysis of mitochondrial DNA polymorphisms in Guangdong Han Chinese[J]. FORENSIC SCIENCE INTERNATIONAL-GENETICS,2008,2(2):150-153.
APA	Chen F.,Wang SY[].,Liu YH.,Kong QP[].,Zhang RZ.,...&Gao GF.(2008).Analysis of mitochondrial DNA polymorphisms in Guangdong Han Chinese.FORENSIC SCIENCE INTERNATIONAL-GENETICS,2(2),150-153.
MLA	Chen F,et al."Analysis of mitochondrial DNA polymorphisms in Guangdong Han Chinese".FORENSIC SCIENCE INTERNATIONAL-GENETICS 2.2(2008):150-153.