Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子人类学

	Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians
	He YH 1,2; Lu X 1,2; Yang LQ 1,2; Xu LY 3; Kong QP[*]1,2
刊名	AGING
	2014
卷号	6 期号:11 页码:944-956
关键词	insulin-like growth factor binding protein 3 longevity single nucleotide polymorphism
通讯作者	kongqp@mail.kiz.ac.cn
合作状况	其它
英文摘要	Human lifespan is determined greatly by genetic factors and some investigations have identified putative genes implicated in human longevity. Although some genetic loci have been associated with longevity, most of them are difficult to replicate due to ethnic differences. In this study, we analyzed the association of 18 reported gene single nucleotide polymorphisms (SNPs) with longevity in 1075 samples consisting of 567 nonagenarians/centenarians and 508 younger controls using the GenomeLab SNPstream Genotyping System. Our results confirm the association of the forkhead box O3 (FOXO3) variant (rs13217795) and the ATM serine/threonine kinase (ATM) variant (rs189037) genotypes with longevity (p=0.0075 and p=0.026, using the codominant model and recessive model, respectively). Of note is that we first revealed the association of insulin-like growth factor binding protein 3 (IGFBP-3) gene polymorphism rs11977526 with longevity in Chinese nonagenarians/centenarians (p=0.033 using the dominant model and p=0.035 using the overdominant model). The FOXO3 and IGFBP-3 form important parts of the insulin/insulin-like growth factor-1 signaling pathway (IGF-1) implicated in human longevity, and the ATM gene is involved in sensing DNA damage and reducing oxidative stress, therefore our results highlight the important roles of insulin pathway and oxidative stress in the longevity in the Chinese population.
收录类别	SCI
资助信息	This work was supported by grants from National Basic Research Program of China (2013CB530802), Yunnan Province (2011FA024, 2013FB069), the Chinese Academy of Sciences, Natural Science Foundation of China (31123005, 31322029).
语种	英语
WOS记录号	WOS:000348055200004
公开日期	2015-02-13
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8260]
专题	昆明动物研究所_分子人类学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China 3.Dujiangyan Longevity Research Centre, Dujiangyan 611830, China
推荐引用方式 GB/T 7714	He YH,Lu X,Yang LQ,et al. Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians[J]. AGING,2014,6(11):944-956.
APA	He YH,Lu X,Yang LQ,Xu LY,&Kong QP[*].(2014).Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians.AGING,6(11),944-956.
MLA	He YH,et al."Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians".AGING 6.11(2014):944-956.