Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子人类学

	Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals
	Liu YW 1,3,4; He YH 1,3; Zhang YX 2; Cai WW[]1,2; Yang LQ 1,3; Xu LY 5; Kong QP[]1,3
刊名	NEUROBIOLOGY OF AGING
	2014
卷号	35 期号:4 页码:935(e11-e12)
关键词	Alzheimer's disease Amyloid precursor protein A673T Longevity Chinese
通讯作者	caiww591020@163.com ; kongqp@mail.kiz.ac.cn
合作状况	其它
英文摘要	A673T, a rare variant in the amyloid-beta precursor protein gene, shows a protective potential against Alzheimer's disease (AD) and age-related cognitive decline in an Icelandic population. Although A673T was observed independently in a Finnish population, this variant was absent in 8721 Asian subjects. The conflicting observations suggest that the contribution of A673T may be confined to Europeans and Americans rather than Asians. Nevertheless, A673T confers a protective function against AD and thus may be observed only in longevity subjects; thus it is not surprising to see its absence when the general populations or the patient cohorts were considered. To test whether the A673T contributes to the Chinese population, 1237 healthy longevity subjects (mean age 96.9 years) and 1404 matched younger controls (mean age 44.2 years) were genotyped for the variant. Our study failed to observe this variant in either the longevity subjects or the controls. Given the previous observation from Asians, our results suggest that the A673T variant is not involved in longevity in Chinese individuals; some other protective mechanisms may contribute to a lower incidence of AD in Chinese nonagenerians and centenarians.
收录类别	SCI
资助信息	This work was supported by grants from the National Basic Research Program of China (2013CB530802), Yunnan Province (2011FA024), the Chinese Academy of Sciences, and Natural Science Foundation of China (31100909 and 31322029), and the Department of Science and Technology of Hainan Province (013GHXM0025 and ZDXM20090805).
语种	英语
WOS记录号	WOS:000330283300029
公开日期	2014-02-20
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7804]
专题	昆明动物研究所_分子人类学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, China 3.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 4.University of the Chinese Academy of Sciences, Beijing, China 5.Dujiangyan Longevity Research Centre, Dujiangyan, China
推荐引用方式 GB/T 7714	Liu YW,He YH,Zhang YX,et al. Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals[J]. NEUROBIOLOGY OF AGING,2014,35(4):935(e11-e12).
APA	Liu YW.,He YH.,Zhang YX.,Cai WW[].,Yang LQ.,...&Kong QP[].(2014).Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals.NEUROBIOLOGY OF AGING,35(4),935(e11-e12).
MLA	Liu YW,et al."Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals".NEUROBIOLOGY OF AGING 35.4(2014):935(e11-e12).