The role of ROS toxicity in spontaneous aneuploidy in cultured cells

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子人类学

	The role of ROS toxicity in spontaneous aneuploidy in cultured cells
	Wang CY[*]1; Liu LN 2; Zhao ZB 3
刊名	TISSUE & CELL
	2013
卷号	45 期号:1 页码:47-53
关键词	Aneuploidy Chromosome Reactive oxygen species Cell culture
通讯作者	chengyewang@yahoo.com.cn
合作状况	其它
英文摘要	It is well known that the karyotype of animal cells cultured in vitro tends to become aneuploid as the culture ages. Aneuploidy can cause genetic instability, alter the biological properties of cells, and affect their application in genetic studies and cell engineering. Understanding the causes and mechanisms of aneuploidy is primary to control its occurrence in cultured cells, and is also helpful to understand the mechanisms of tumorigenesis because aneuploidy is a hallmark of tumor cells. This review underscores the potential role of reactive oxygen species (ROS) toxicity in spontaneous aneuploidy of cultured cells. The underlying mechanisms and possible sources of ROS are also discussed.
收录类别	SCI
资助信息	This work was supported by a grant from the National Natural Science Foundation of China (No. 31101668).
语种	英语
WOS记录号	WOS:000321560800006
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7666]
专题	昆明动物研究所_分子人类学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Key Laboratory of Cultivating and Utilization of Resource Insects of State Forestry Administration, Research Institute of Resource Insects, Chinese Academy of Forestry, Kunming 650224, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Department of Ecology, Environmental Management College of China, Qinhuangdao 066004, China
推荐引用方式 GB/T 7714	Wang CY[*],Liu LN,Zhao ZB. The role of ROS toxicity in spontaneous aneuploidy in cultured cells[J]. TISSUE & CELL,2013,45(1):47-53.
APA	Wang CY[*],Liu LN,&Zhao ZB.(2013).The role of ROS toxicity in spontaneous aneuploidy in cultured cells.TISSUE & CELL,45(1),47-53.
MLA	Wang CY[*],et al."The role of ROS toxicity in spontaneous aneuploidy in cultured cells".TISSUE & CELL 45.1(2013):47-53.