Distinctive Paleo-Indian Migration Routes from Beringia Marked by Two Rare mtDNA Haplogroups

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	Distinctive Paleo-Indian Migration Routes from Beringia Marked by Two Rare mtDNA Haplogroups
	Perego UA 1,2; Achilli A 1,3; Angerhofer N 2; Accetturo M 1; Pala M 1; Olivieri A 1; Kashani BH 1; Ritchie KH 2; Scozzari R 4; Kong QP 5,6
刊名	CURRENT BIOLOGY
	2009
卷号	19 期号:1 页码:37629
ISSN号	0960-9822
通讯作者	torroni@ipvgen.unipv.it
合作状况	其它
英文摘要	Background: It is widely accepted that the ancestors of Native Americans arrived in the New World via Beringia approximately 10 to 30 thousand years ago (kya). However, the arrival time(s), number of expansion events, and migration routes into the Western Hemisphere remain controversial because linguistic, archaeological, and genetic evidence have not yet provided coherent answers. Notably, most of the genetic evidence has been acquired from the analysis of the common pan-American mitochondrial DNA (mtDNA) haplogroups. In this study, we have instead identified and analyzed mtDNAs belonging to two rare Native American haplogroups named D4h3 and X2a. Results: Phylogeographic analyses at the highest level of molecular resolution (69 entire mitochondrial genomes) reveal that two almost concomitant paths of migration from Beringia led to the Paleo-Indian dispersal approximately 15-17 kya. Haplogroup D4h3 spread into the Americas along the Pacific coast, whereas X2a entered through the ice-free corridor between the Laurentide and Cordilleran ice sheets. The examination of an additional 276 entire mtDNA sequences provides similar entry times for all common Native American haplogroups, thus indicating at least a dual origin for Paleo-Indians. Conclusions: A dual origin for the first Americans is a striking novelty from the genetic point of view, and it makes plausible a scenario positing that within a rather short period of time, there may have been several entries into the Americas from a dynamically changing Beringian source. Moreover, this implies that most probably more than one language family was carried along with the Paleo-Indians.
收录类别	SCI
资助信息	This research received support from Progetti Ricerca Inter- esse Nazionale 2007 (Italian Ministry of the University) (to R.S., O.S., and A.T.), the Sorenson Molecular Genealogy Foundation (to S.R.W.), Compag- nia di San Paolo (to O.S. and A.T.), and Fondazione Cariplo (to A.T.).
原文出处	20091911.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4783]
专题	昆明动物研究所_分子人类学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Dipartimento di Genetica e Microbiologia Universita ` di Pavia 27100 Pavia Italy 2.Sorenson Molecular Genealogy Foundation Salt Lake City, UT 84115 USA 3.Dipartimento di Biologia Cellulare e Ambientale Universita ` di Perugia 27100 Perugia Italy 4.Dipartimento di Genetica e Biologia Molecolare Universita ` La Sapienza 00185 Rome Italy 5.State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences 650223 Kunming, Yunnan China 6.Laboratory for Conservation and Utilization of Bio-resource Yunnan University 650223 Kunming, Yunnan China 7.Unidade de Xene ´tica Instituto de Medicina Legal Facultad de Medicina Universidad de Santiago de Compostela 15782 Santiago de Compostela, Galicia Spain 8.Department of Mathematics University of Hamburg 20146 Ham
推荐引用方式 GB/T 7714	Perego UA,Achilli A,Angerhofer N,et al. Distinctive Paleo-Indian Migration Routes from Beringia Marked by Two Rare mtDNA Haplogroups[J]. CURRENT BIOLOGY,2009,19(1):37629.
APA	Perego UA.,Achilli A.,Angerhofer N.,Accetturo M.,Pala M.,...&Torroni A[*].(2009).Distinctive Paleo-Indian Migration Routes from Beringia Marked by Two Rare mtDNA Haplogroups.CURRENT BIOLOGY,19(1),37629.
MLA	Perego UA,et al."Distinctive Paleo-Indian Migration Routes from Beringia Marked by Two Rare mtDNA Haplogroups".CURRENT BIOLOGY 19.1(2009):37629.