Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina
	Hu QX 1,2; Fan Y 1,2; Xu L 1,2; Pang W 1; Wang SQ[1]1; Zheng YT 1,2,3; Lv LB 3; Yao YG[*]1,2,3
刊名	GENE
	2015
卷号	517 期号:2 页码:279-285
关键词	Gene conversion NUMT Phylogeny Pig-tailed monkey Tandem repeat mtDNA
通讯作者	yaoyg@mail.kiz.ac.cn
合作状况	其它
英文摘要	As a non-human primate, the pig-tailed macaque has received wide attention because it can be infected by HIV-1. In this study, we determined the complete mtDNA sequence of the northern pig-tailed macaque (Macaca leonina). Unexpectedly, during the amplification of the mtDNA control region (D-loop region) we observed several D-loop-like sequences, which were NUMTs (nuclear mitochondrial sequences) and a total of 14 D-loop-like NUMT haplotypes were later identified in five individuals. The neighbor-joining tree and estimated divergence time based on these D-loop-like NUMT sequences of M. leonina provide some insights into the understanding of the evolutionary history of NUMTs. D-loop-like haplotypes G and H, which also exist in the nuclear genome of mulatta, appear to have been translocated into the nuclear genome before the divergence of M. mulatta and M. leonina. The other D-loop-like NUMT haplotypes were translocated into the nuclear genome of M. leonina after the divergence of the two species. Later sequence conversion was predicted to occur among these 14 D-loop-like NUMT haplotypes. The overall structure of the mtDNA of M. leonina was found to be similar to that seen in other mammalian mitochondrial genomes. Phylogenetic analysis based on the maximum likelihood method shows M. leonina clustered with Macaca silenus among the analyzed mammalian species.
收录类别	SCI
资助信息	This study was supported by the 135 strategic project of Kunming Institute of Zoology, Chinese Academy of Sciences. Y.-T. Z. was sup- ported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-R-13).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9375]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_分子免疫药理学昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Hu QX,Fan Y,Xu L,et al. Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina[J]. GENE,2015,517(2):279-285.
APA	Hu QX.,Fan Y.,Xu L.,Pang W.,Wang SQ[1].,...&Yao YG[*].(2015).Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina.GENE,517(2),279-285.
MLA	Hu QX,et al."Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina".GENE 517.2(2015):279-285.