Mitochondrial DNA Haplogroup A Decreases the Risk of Drug Addiction but Conversely Increases the Risk of HIV-1 Infection in Chinese Addicts

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	Mitochondrial DNA Haplogroup A Decreases the Risk of Drug Addiction but Conversely Increases the Risk of HIV-1 Infection in Chinese Addicts
	Zhang AM 1; Hu QX 1; Zhang W 1; Guo H 1,3; Logan I 4; Zheng YT[]1,5; Yao YG[]1,5; Liu FL 1; Bi R 1; Yang BQ 2
刊名	Molecular Neurobiology
	2016
卷号	53 期号:6 页码:3873-3881
关键词	Drug addiction mtDNA haplogroup HIV-1 infection Chinese
通讯作者	zhengyt@mail.kiz.ac.cn
合作状况	其它
英文摘要	Drug addiction is one of the most serious social problems in the world today and addicts are always at a high risk of acquiring HIV infection. Mitochondrial impairment has been reported in both drug addicts and in HIV patients undergoing treatment. In this study, we aimed to investigate whether mitochondrial DNA (mtDNA) haplogroup could affect the risk of drug addiction and HIV-1 infection in Chinese. We analyzed mtDNA sequence variations of 577 Chinese intravenous drug addicts (289 with HIV-1 infection and 288 without) and compared with 2 control populations (n = 362 and n = 850). We quantified the viral load in HIV-1-infected patients with and without haplogroup A status and investigated the potential effect of haplogroup A defining variants m.4824A > G and m.8794C > T on the cellular reactive oxygen species (ROS) levels by using an allotopic expression assay. mtDNA haplogroup A had a protective effect against drug addiction but appeared to confer an increased risk of HIV infection in addicts. HIV-1-infected addicts with haplogroup A had a trend for a higher viral load, although the mean viral load was similar between carriers of haplogroup A and those with other haplogroup. Hela cells overexpressing allele m.8794 T showed significantly decreased ROS levels as compared to cells with the allele m.8794C (P = 0.03). Our results suggested that mtDNA haplogroup A might protect against drug addiction but increase the risk of HIV-1 infection. The contradictory role of haplogroup A might be caused by an alteration in mitochondrial function due to a particular mtDNA ancestral variant
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9340]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_分子免疫药理学
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, China 2.Department of Laboratory Medicine Science, Dehong Prefecture People’s Hospital of Yunnan Province, Yunnan, China 3.Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China 4.Exmouth, Devon, UK 5.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Zhang AM,Hu QX,Zhang W,et al. Mitochondrial DNA Haplogroup A Decreases the Risk of Drug Addiction but Conversely Increases the Risk of HIV-1 Infection in Chinese Addicts[J]. Molecular Neurobiology,2016,53(6):3873-3881.
APA	Zhang AM.,Hu QX.,Zhang W.,Guo H.,Logan I.,...&Yang BQ.(2016).Mitochondrial DNA Haplogroup A Decreases the Risk of Drug Addiction but Conversely Increases the Risk of HIV-1 Infection in Chinese Addicts.Molecular Neurobiology,53(6),3873-3881.
MLA	Zhang AM,et al."Mitochondrial DNA Haplogroup A Decreases the Risk of Drug Addiction but Conversely Increases the Risk of HIV-1 Infection in Chinese Addicts".Molecular Neurobiology 53.6(2016):3873-3881.