Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5 | |
Mu D1,2; Yang H3; Zhu JW1,2; Liu FL1; Tian RR1,2; Zheng HY1,4; Han JB1; Shi P[*]3; Zheng YT[*]1,2,5 | |
刊名 | MOLECULAR BIOLOGY AND EVOLUTION |
2014 | |
卷号 | 33期号:11页码:2985-2997 |
通讯作者 | ship@mail.kiz.ac.cn ; zhengyt@mail.kiz.ac.cn. |
英文摘要 | The origin of novel genes and their evolutionary fates are long-standing questions in evolutionary biology. These questions become more complicated for genes conserved across various lineages, such as TRIM5, an antiretroviral restriction factor and a retrovirus capsid sensor in immune signaling. TRIM5 has been subjected to numerous pathogenic challenges and undergone dynamic evolution, making it an excellent example for studying gene diversification. Previous studies among several species showed that TRIM5 gained genetic and functional novelty in a lineage-specific manner, either through gene duplication or a cyclophilin A retrotransposing into the TRIM5 locus, creating the gene fusion known as TRIM5-Cyclophilin A (TRIMCyp). To date, the general pattern of TRIM5 across the mammalian lineage remains elusive. In this study, we surveyed 36 mammalian genomes to verify a potentially novel TRIM5 pattern that uniquely seems to have occurred in tree shrews (Tupaia belangeri), and found that both gene duplication and retrotransposition worked jointly to form a specific TRIM5/TRIMCyp cluster not found among other mammals. Evolutionary analyses showed that tree shrew TRIMCyp (tsTRIMCyp) originated independently in comparison with previously reported TRIMCyps and underwent strong positive selection, whereas no signal of positive selection was detected for other tree shrew TRIM5 (tsTRIM5) genes. Functional assay results suggest a functional divergence between tsTRIMCyp and its closest paralog TRIM5-4, likely reflecting different fates under diverse evolutionary forces. These findings present a rare example of novel gene origination resulting from a combination of gene duplication, retrotransposition, and exon shuffling processes, providing a new paradigm to study genetic innovations and evolutionary fates of duplicated genes. |
收录类别 | SCI |
资助信息 | Thiswork was supported by the grand from the 863 Program of China (2012AA021801),theNationalNaturalScienceFoundationof China (U0832601, 30671960, 81172876, 81202366, 31123005, 31325013), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-23, KSCX2-EW- R-13, KSCX2-EW-R-12, KJZD-EW-L10-02), the National Basic Research Program of China (2012CBA01305, 2006CB504302), and Yunnan (2013FB073). |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/9256] |
专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与功能基因组学 昆明动物研究所_中国科学院昆明灵长类研究中心 |
作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 4.University of Science and Technology of China, Hefei, China 5.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, China |
推荐引用方式 GB/T 7714 | Mu D,Yang H,Zhu JW,et al. Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5[J]. MOLECULAR BIOLOGY AND EVOLUTION,2014,33(11):2985-2997. |
APA | Mu D.,Yang H.,Zhu JW.,Liu FL.,Tian RR.,...&Zheng YT[*].(2014).Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5.MOLECULAR BIOLOGY AND EVOLUTION,33(11),2985-2997. |
MLA | Mu D,et al."Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5".MOLECULAR BIOLOGY AND EVOLUTION 33.11(2014):2985-2997. |
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