The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques
	Wang RR 1; Au KY 2; Zheng HY 1; Gao LM 3; Zhang X 1; Luo RH 1; Law SKY 2; Mak ANS 2; Wong KB 2; Zhang MX 1
刊名	TOXINS
	2015
卷号	7 期号:1 页码:156-169
关键词	maize RIP anti-HIV animal model viral load
通讯作者	pcshaw@cuhk.edu.hk
合作状况	其它
英文摘要	Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation loop which is proteolytically removed for full catalytic activity. Here, we showed that the recombinant active maize RIP protected chimeric simian-human immunodeficiency virus (SHIV) 89.6-infected macaque peripheral blood mononuclear cells from lysis ex vivo and transiently reduced plasma viral load in SHIV89.6-infected rhesus macaque model. No evidence of immune dysregulation and other obvious side-effects was found in the treated macaques. Our work demonstrates the potential development of maize RIP as an anti-HIV agent without impeding systemic immune functions.
收录类别	SCI
资助信息	Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452).
语种	英语
公开日期	2015-03-02
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8268]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Center for Protein Science and Crystallography, School of Life Sciences, the Chinese University of Hong Kong, Shatin N.T. 999077, Hong Kong, China 3.Division of HIV/AIDS and STI Control, Yuxi Centers for Disease Control and Prevention, Yuxi 653100, Yunnan, China
推荐引用方式 GB/T 7714	Wang RR,Au KY,Zheng HY,et al. The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques[J]. TOXINS,2015,7(1):156-169.
APA	Wang RR.,Au KY.,Zheng HY.,Gao LM.,Zhang X.,...&Zheng YT[*].(2015).The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques.TOXINS,7(1),156-169.
MLA	Wang RR,et al."The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques".TOXINS 7.1(2015):156-169.