Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr
	Huang SZ 1,2; Zhang X 3; Ma QY 1; Peng H 2; Zheng YT 3; Hu JM 2; Dai HF 1; Zhou J[]2; Zhao YX[]1
刊名	FITOTERAPIA
	2014
卷号	95 期号:X 页码:34-41
关键词	Anti-HIV-1 Chemotaxonomy Excoecaria acerifolia Euphorbiaceae Excoecafolin
通讯作者	junzhou3264@126.com ; zhaoyx1011@163.com
合作状况	其它
英文摘要	Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerzfolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 mu M, SI >1,836.9,431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.
收录类别	SCI
资助信息	This work was financially supported by the National Natural Science Foundation of China (31300294), the Special Fund for Agro-scientific Research in the Public Interest (201303117), the National Support Science and Technology Subject (2013BAI11B04), and the Major Technology Project of Hainan (ZDZX2013008-4, ZDZX2013023-1).
语种	英语
WOS记录号	WOS:000336819400005
公开日期	2014-10-15
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8042]
专题	昆明动物研究所_分子免疫药理学
作者单位	1.Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, PR China
推荐引用方式 GB/T 7714	Huang SZ,Zhang X,Ma QY,et al. Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr[J]. FITOTERAPIA,2014,95(X):34-41.
APA	Huang SZ.,Zhang X.,Ma QY.,Peng H.,Zheng YT.,...&Zhao YX[*].(2014).Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr.FITOTERAPIA,95(X),34-41.
MLA	Huang SZ,et al."Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr".FITOTERAPIA 95.X(2014):34-41.