Bioactive Dibenzocyclooctadiene Lignans  from the Stems of Schisandra neglecta

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta
	Gao XM 1,2; Wang RR 4; Niu DY 2,3; Meng CY 2,3; Yang LM 4; Zheng YT 4; Yang GY 1,3; Hu QF[]2; Sun HD 1; Xiao WL[]1
刊名	JOURNAL OF NATURAL PRODUCTS
	2013
卷号	76 期号:6 页码:1052-1057
通讯作者	huqiufena@yahoo.com.cn ; xwl@mail.kib.ac.cn
合作状况	其它
英文摘要	Seven new unusual dibenzocyclooctadiene lignans, neglignans A-G (1-7), together with 16 known dibenzocyclooctadiene lignans, were isolated from the stems of Schisandra neglecta. Compounds 1 and 2 are the first dibenzocyclooctadiene lignans bearing a carboxyl group at C-4, and compounds 3 and 4 are the first 7,8-seco-dibenzocyclooctadiene lignans found from Nature. The new compounds (1-7) and several of the known compounds were evaluated for their anti-HIV activity and cytotoxicity. Compounds 2 and 6 showed anti-HIV-1 activities with therapeutic index values greater than 50, and compound 4 showed cytotoxicity against the NB4 and SHSY5Y cancer cell lines with IC50 values of 2.9 and 3.3 mu M, respectively.
收录类别	SCI
资助信息	This project was supported financially by CAS grants (KSCX2- EW-Q-10 and KSCX1-YW-R-24), the Natural Science Foundation of Yunnan Province (No. 2012FB178), the NSFC (Nos. 20802082 and 30830115), the 973 Programs (Nos. 2009CB522300 and 2009CB940900), the Excellent Scientific and Technological Team of Yunnan Higher Education (2010CI08), and the Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team (2011HC008).
语种	英语
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7612]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People’s Republic of China 2.Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People’s Republic of China 3.Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, Yunnan, People’s Republic of China 4.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, People’s Republic of China
推荐引用方式 GB/T 7714	Gao XM,Wang RR,Niu DY,et al. Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(6):1052-1057.
APA	Gao XM.,Wang RR.,Niu DY.,Meng CY.,Yang LM.,...&Xiao WL[*].(2013).Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta.JOURNAL OF NATURAL PRODUCTS,76(6),1052-1057.
MLA	Gao XM,et al."Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta".JOURNAL OF NATURAL PRODUCTS 76.6(2013):1052-1057.