An HIV-1 Resistance Polymorphism in TRIM5 alpha Gene Among Chinese Intravenous Drug Users

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	An HIV-1 Resistance Polymorphism in TRIM5 alpha Gene Among Chinese Intravenous Drug Users
	Liu FL 1,2,3; Qiu YQ 4; Li H 5; Kuang YQ 1,2,3; Tang X 1,2,3; Cao GA 1,2,3; Tang NLS[]2,4,6; Zheng YT[]1,2
刊名	JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
	2011
卷号	56 期号:4 页码:306-311
关键词	Chinese HIV-1 IDU TRIM5 alpha polymorphism susceptibility
通讯作者	nelsontang@cuhk.edu.hk ; zhengyt@mail.kiz.ac.cn
合作状况	其它
英文摘要	Background: TRIM5 alpha has species-specific restriction activity against replication of many retroviruses, including HIV-1. Though human also express TRIM5 alpha protein, it is less potent in suppressing infection of HIV-1 than most orthologs of other nonhuman primates. Previous association studies suggested that polymorphisms in TRIM5 alpha gene might protect against HIV-1 infection. However, the exact variation accounting for this protective effect was not certain. Methods: One thousand two hundred ninety-four Chinese intravenous drug users (IDUs), including 1011 Hans and 283 Dai subjects, were investigated for sequence variations in TRIM5 alpha and association with HIV-1 resistance. Resequencing of the putative functional domains in exon2 and exon8 was carried out in 1151 subjects, along with exon2 resequencing in a further 143 HIV-1-infected IDUs. Results: We identified 14 different nucleotide variants, including 4 with minor allele frequency >0.05. We observed that the frequency of 43Y homozygote in seronegative IDUs was significantly higher than that in the HIV-1-infected IDUs, suggesting a protective effect among the homozygote subjects [ odds ratio (95% confidence interval) = 0.46 (0.22 to 0.94), P = 0.033, Mantel-Haenszel test]. Conclusions: we concluded that H43Y might account for the HIV-1 resistance due to TRIM5 alpha gene in Chinese IDUs.
收录类别	SCI
资助信息	Supported by National Basic Research Program of China (2006CB504302, 2006CB504208, 2009CB522306), National Natural Science Foundation of China (30671960, U0832601, 30872317, 30800113), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185), and Eleventh Five- Year Key Scientific and Technological Program of China (2008ZX10001- 002, 2008ZX10001-015, 2009ZX10004-902, 2008ZX10005-005, 2009ZX09501-029).
语种	英语
公开日期	2011-03-17
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6587]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan, China 3.Graduate School of Chinese Academy of Sciences, Beijing, China 4.Departments of Chemical Pathology, Faculty of Medicine, The Chinese Universityof Hong Kong, Hong Kong, China 5.Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, China 6.Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
推荐引用方式 GB/T 7714	Liu FL,Qiu YQ,Li H,et al. An HIV-1 Resistance Polymorphism in TRIM5 alpha Gene Among Chinese Intravenous Drug Users[J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,2011,56(4):306-311.
APA	Liu FL.,Qiu YQ.,Li H.,Kuang YQ.,Tang X.,...&Zheng YT[*].(2011).An HIV-1 Resistance Polymorphism in TRIM5 alpha Gene Among Chinese Intravenous Drug Users.JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,56(4),306-311.
MLA	Liu FL,et al."An HIV-1 Resistance Polymorphism in TRIM5 alpha Gene Among Chinese Intravenous Drug Users".JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 56.4(2011):306-311.