6-(1H-吲哚-3-甲基)-5-乙基-3H-嘧啶-4-酮类化合物的合成及抗HIV活性研究 | |
李大雄1; 龙晶2; 林海娇1; 李聪1; 郑永唐[*]2; 何严萍[*]1 | |
刊名 | 云南大学学报(自然科学版) |
2010 | |
期号 | 5页码:572 - 576 |
关键词 | HIV 非核苷类逆转录酶抑制剂 二氢烷氧苄基嘧啶酮类化合物 抗HIV活性 |
其他题名 | Synthesis and Anti-HIV Activity of 6-((1H-indol-3-yl) methyl)-5-ethyl-pyrimidin-4(3H)-one Analogues |
合作状况 | 其它 |
中文摘要 | 基于二氢烷氧苄基嘧啶酮(DABO)类非核苷类逆转录酶抑制剂(NNRTIs)的构效关系研究,设计合成了2个新的6-(1H-吲哚-3-甲基)-5-乙基-3H-嘧啶-4-酮类化合物,并采用C8166细胞进行了体外抗HIV活性测试,为新型S-DABO类非核苷类逆转录酶抑制剂结构修饰提出了新的设想. |
英文摘要 | To analysize the chemical constituents of the essential oil from different parts(organs) of Chimo- nanthus nitens Oliv. distributed in Guizhou province. Essential oil was obtained by steam distillation from the root, stem, leaves and pericarp of Chimonanthus nitens. The chemical constituents were identified by GC - MS method, and the relative content of each constituent determined by area normalization. Seventy - six components were i- dentified and 8 compounds were coexisted in the root, stem, leaves and pericarp, which took up 43. 08%, 7. 87%, 57. 55% and 66. 72% ratio of the essential oil of each organ, respectively. 1, 8 - Cineole, erpinene -4 - ol and linayl propionate were found to be the major constituent in the root essential oil, while elemol and β - eu- desmol in the leaves essential oil,borneol , 1, 8 - Cineole and α - cadinol in stem essential oil and caryophyllene oxide and humulene epoxide in the pericarp essential oil. The results showed that stem and pericarp contained al- most same essential chemical constituents but were different from those of root and leaf. |
收录类别 | 其他 |
资助信息 | 国家自然科学基金资助项目(30560179,30960459). |
语种 | 中文 |
公开日期 | 2010-11-10 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.42:8088/handle/152453/6406] |
专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
作者单位 | 1.云南大学化学科学与工程学院,教育部自然资源药物化学重点实验室,云南 昆明 650091 2.中国科学院昆明动物研究所,动物模型与人类疾病机理重点实验室,云南 昆明 650223 |
推荐引用方式 GB/T 7714 | 李大雄,龙晶,林海娇,等. 6-(1H-吲哚-3-甲基)-5-乙基-3H-嘧啶-4-酮类化合物的合成及抗HIV活性研究[J]. 云南大学学报(自然科学版),2010(5):572 - 576. |
APA | 李大雄,龙晶,林海娇,李聪,郑永唐[*],&何严萍[*].(2010).6-(1H-吲哚-3-甲基)-5-乙基-3H-嘧啶-4-酮类化合物的合成及抗HIV活性研究.云南大学学报(自然科学版)(5),572 - 576. |
MLA | 李大雄,et al."6-(1H-吲哚-3-甲基)-5-乙基-3H-嘧啶-4-酮类化合物的合成及抗HIV活性研究".云南大学学报(自然科学版) .5(2010):572 - 576. |
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