Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum
	Lin HW 1; Sun MX 1; Wang YH 2; Yang LM 2; Yang YR 2; Huang N 2; Xuan LJ 3; Xu YM 3; Bai DL 3; Zheng YT[*]2
刊名	PLANTA MEDICA
	2010
卷号	76 期号:9 页码:889-892
关键词	Polygonum cuspidatum Polygonum multiflorum Polygonaceae chemical components anti-HIV-1 activity
ISSN号	0032-0943
通讯作者	zhengyt@mail.kiz.ac.cn ; kaixiaocn@gmail.com
合作状况	其它
英文摘要	The 70% EtOH extract of Polygonum cuspidatum showed inhibitory action against HIV-1-induced syncytium formation at non-cytotoxic concentrations in vitro with a 50% effective concentration (EC50) of 13.94 +/- 3.41 mu g/mL. Through bioactivity-guided fractionation, 20 phenolic compounds, including eight stilbenoids, were isolated from the roots of Polygonum cuspidatum, and their anti-HIV-1 activities were evaluated. Results showed that compounds 1, 13, 14, and 16 demonstrated fairly strong antiviral activity against HIV-1-induced cytopathic effects in C8166 lymphocytes at non-cytotoxic concentrations, with EC50 values of 4.37 +/- 1.96 mu g/mL, 19.97 +/- 5.09, 14.4 +/- 1.34 mu g/mL, and 11.29 +/- 6.26 mu g/mL and therapeutic index (TI) values of 8.12, > 10.02, > 13.89, and > 17.71, respectively. Other compounds showed either weak or no effects. Compound 6 also showed weak inhibition (153.42 +/- 19.25 mu g/mL); however, it possesses very good water solubility and showed almost no cytotoxicity (> 2000 mu g/mL), therefore achieving a fairly good TI (13.04). The activities of the two compounds (3 and 18) from Polygonum multiflorum were also assayed. The relationship between molecular structures and their bioactivities was also discussed.
收录类别	SCI
资助信息	This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province.
原文出处	2010769889.pdf
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4685]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Lab of Toxicology & Pharmacology, Faculty of Naval Medicine, The Second Military Medical University, Shanghai, P.R. China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Insti- tute of Zoology, Chinese Academyof Sciences, Kunming, P.R. China 3.Shanghai Institute ofMateria Medica, Shanghai Institutes for Biolog- ical Sciences, Chinese Academy of Sciences, Shanghai, P.R. China
推荐引用方式 GB/T 7714	Lin HW,Sun MX,Wang YH,et al. Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum[J]. PLANTA MEDICA,2010,76(9):889-892.
APA	Lin HW.,Sun MX.,Wang YH.,Yang LM.,Yang YR.,...&Xiao K[*].(2010).Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum.PLANTA MEDICA,76(9),889-892.
MLA	Lin HW,et al."Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum".PLANTA MEDICA 76.9(2010):889-892.