| Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis | |
| Wang RR1,3; Gu Q2,3; Yang LM1; Chen JJ2; Li SY4; Zheng YT[*]1 | |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 2006 | |
| 卷号 | 105期号:1-2页码:269-273 |
| 关键词 | Rhus chinensis HIV-1 Anti-HIV activity Botanicals |
| ISSN号 | 0378-8741 |
| 通讯作者 | zhengyt@post.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Rhus chinensis, a species used in folk medicine by Chinese native people, the anti-HIV-1 activities of the petroleum ether, ethyl acetate, butanol and aqueous extract of Rhus chinensis, named as RC-1, RC-2, RC-3 and RC-4, respectively, was evaluated. The petroleum ether extract RC-1 can inhibit the syncytium formation and HIV-1 p24 antigen at non-cytotoxic concentrations, the 50% effective concentration (EC50) were 0.71 and 0.93 microg/ml, respectively. The therapeutic index (TI) was about 100. RC-1 had no activity on inhibiting HIV-1 recombinant RT and HIV-1 entry into host cells. Results showed that RC-1 was effective against HIV-1 and Rhus chinensis would be a useful medicinal plant for the chemotherapy of HIV-1 infection. RC-1 might inhibit the post steps or target the new sites of HIV-1 replication. |
| 收录类别 | SCI |
| 资助信息 | The work was supported by grants from the Natural Sci- ence Foundation of China (30471605), the Natural Science Foundation of Yunnan (2003C0001R), Key Scientific and Tech- nological projects of China (2004BA719A14) and Yunnan province (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216 and KSCX1-SW-11) and National 863 Pro- gram (2003AA219142). |
| 原文出处 | 2006105269.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 内容类型 | 期刊论文 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4563]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 4.Faculty of Pharmaceutical Sciences, Kunming Medical College, Kunming, Yunnan 650031, China |
| 推荐引用方式 GB/T 7714 | Wang RR,Gu Q,Yang LM,et al. Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):269-273. |
| APA | Wang RR,Gu Q,Yang LM,Chen JJ,Li SY,&Zheng YT[*].(2006).Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis.JOURNAL OF ETHNOPHARMACOLOGY,105(1-2),269-273. |
| MLA | Wang RR,et al."Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis".JOURNAL OF ETHNOPHARMACOLOGY 105.1-2(2006):269-273. |
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