Zinc coupling potentiates anti-HIV-1 activity of baicalin

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Zinc coupling potentiates anti-HIV-1 activity of baicalin
	Wang Q 1,3; Wang YT 2; Pu SP 2; Zheng YT[*]1
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2004
卷号	324 期号:2 页码:605-610
关键词	Baicalin HIV-1 RT HIV entry Anti-HIV activity
ISSN号	0006-291X
通讯作者	zhengyt@mail.kiz.ac.cn
合作状况	其它
英文摘要	Baicalin (BA) has been shown with anti-HIV-1 activity. Zinc is a nutrient element. The anti-HIV-1 activity of zinc complex of baicalin (BA-Zn) in vitro was studied and compared with the anti-HIV-1 activities between BA and BA-Zn in the present study. Our results suggested that BA-Zn has lower cytotoxicity and higher anti-HIV-1 activity compared with those of BA in vitro. The CC50s of BA-Zn and BA were 221.52 and 101.73 microM, respectively. The cytotoxicity of BA-Zn was about 1.2-fold lower than that of BA. The BA and BA-Zn inhibited HIV-1 induced syncytium formation, HIV-1 p24 antigen and HIV-1 RT production. The EC50s of BA-Zn on inhibiting HIV-1 induced syncytium formation (29.08 microM) and RT production (31.17 microM) were lower than those of BA (43.27 and 47.34 microM, respectively). BA-Zn was more effective than BA in inhibiting the activities of recombinant RT and HIV-1 entry into host cells. Zinc coupling enhanced the anti-HIV-1 activity of baicalin.
收录类别	SCI
资助信息	The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142).
原文出处	2004324605.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4531]
专题	昆明动物研究所_分子免疫药理学
作者单位	1.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 2.Kunming Institute of Precious Metals, Kunming 650221, PR China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
推荐引用方式 GB/T 7714	Wang Q,Wang YT,Pu SP,et al. Zinc coupling potentiates anti-HIV-1 activity of baicalin[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,324(2):605-610.
APA	Wang Q,Wang YT,Pu SP,&Zheng YT[*].(2004).Zinc coupling potentiates anti-HIV-1 activity of baicalin.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,324(2),605-610.
MLA	Wang Q,et al."Zinc coupling potentiates anti-HIV-1 activity of baicalin".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 324.2(2004):605-610.