Artificial selection of the melanocortin receptor 1 gene in Chinese domestic pigs during domestication

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Artificial selection of the melanocortin receptor 1 gene in Chinese domestic pigs during domestication
	Li J 1,2; Yang H 2; Pan XR 1; Shi P[]2; Zhang YP[]1,2; Li JR 3; Li HP 3; Ning T 1,2
刊名	HEREDITY
	2010-08-16
卷号	105 期号:3 页码:274-281
关键词	coat colour domestic animal population genetics evolution
通讯作者	ship@mail.kiz.ac.cn ; zhangyp@mail.kiz.ac.cn
合作状况	其它
英文摘要	Black coat colour is common in Chinese indigenous domestic pigs, but not among their wild ancestors, and it is thus presumed to be a 'domestication trait.' To determine whether artificial interference contributes to morphological diversification, we examined nucleotide variation from 157 Chinese domestic pigs and 40 wild boars in the melanocortin receptor 1 (MC1R) gene, which has a key role in the coat pigmentation of Sus scrofa. Compared with a pseudogene GPIP, our results showed that the joint effects of demography and selection have resulted in markedly low genetic diversity of MC1R in Chinese domestic pigs. Coalescent simulation and selection tests further suggest that the fixation of two non-synonymous substitutions associated with black colour is the result of artificial selection. In contrast, a much higher genetic diversity and only a single non-synonymous substitution were found among the wild boars, suggesting a strong functional constraint. Moreover, our conclusion is consistent with the preference for black colour in the ancient Chinese sacrificial culture. This case provides an interesting example of a molecular evaluation of artificial livestock selection and its associated cultural impact in ancient China.
收录类别	SCI
资助信息	The work was supported by grants of the National Basic Research Program of China (973 Program, 2007CB815700, and 2006CB102100), Chinese Academy of Sciences (KSCX2-YW-N-018), Bureau of Science and Technology of Yunnan Province, National Natural Science Foundation of China (30621092, U0836602) and the National 863 Project of China (2008AA101001) to Ya-Ping Zhang, and by a start-up fund of ‘Hundreds-Talent Program’ from Chinese Acad- emy of Sciences Genetically modified organisms breed- ing major projects (2009ZX08009-149B) to Peng Shi.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10449]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_进化与功能基因组学
作者单位	1.Laboratory for Conservation and Utilization of Bio-resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Department of Computational Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
推荐引用方式 GB/T 7714	Li J,Yang H,Pan XR,et al. Artificial selection of the melanocortin receptor 1 gene in Chinese domestic pigs during domestication[J]. HEREDITY,2010,105(3):274-281.
APA	Li J.,Yang H.,Pan XR.,Shi P[].,Zhang YP[].,...&Ning T.(2010).Artificial selection of the melanocortin receptor 1 gene in Chinese domestic pigs during domestication.HEREDITY,105(3),274-281.
MLA	Li J,et al."Artificial selection of the melanocortin receptor 1 gene in Chinese domestic pigs during domestication".HEREDITY 105.3(2010):274-281.