Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome
	Hu BX 1,2,3; Li X 1,2; Chen GJ 1; Zhang YP 4; Fraser NW 5; Wu DD[]4; Zhou JM[]1; Huo YX 1; Yu YF 1,3; Zhang QP 1
刊名	SCIENTIFIC REPORTS
	2016
卷号	6 期号:X 页码:e28075
通讯作者	zhoujm@mail.kiz.ac.cn ; wudongdong@mail.kiz.ac.cn
合作状况	其它
英文摘要	Pathogen invasion triggers a number of cellular responses and alters the host transcriptome. Here we report that the type of changes to cellular transcriptome is related to the type of cellular functions affected by lytic infection of Herpes Simplex Virus type I in Human primary fibroblasts. Specifically, genes involved in stress responses and nuclear transport exhibited mostly changes in alternative polyadenylation (APA), cell cycle genes showed mostly alternative splicing (AS) changes, while genes in neurogenesis, rarely underwent these changes. Transcriptome wide, the infection resulted in 1,032 cases of AS, 161 incidences of APA, 1,827 events of isoform changes, and up regulation of 596 genes and down regulations of 61 genes compared to uninfected cells. Thus, these findings provided important and specific links between cellular responses to HSV-1 infection and the type of alterations to the host transcriptome, highlighting important roles of RNA processing in virus-host interactions.
收录类别	SCI
资助信息	This work was in part supported by grants from Chinese Academy of Sciences (KSCXZ-EW-BR-6), Startup fund from Kunming Institute of Zoology, Chinese Academy of Sciences (Y102421081), Grants from Yunnan Provincial Government (2013FA051), National Science Foundation of China (NSFC 81471966), a Common Project of Panzhihua, Science and Technology Bureau of China (2012CY-S-22(9)), and a Visiting professorship for senior international scientist from CAS to NWF (2012T1S0001).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10231]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_基因调控与表达遗传昆明动物研究所_进化与发育转录组学
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China. 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China. 3.School of Life Sciences, Anhui University, Hefei, Anhui 230601, China 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 5.Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
推荐引用方式 GB/T 7714	Hu BX,Li X,Chen GJ,et al. Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome[J]. SCIENTIFIC REPORTS,2016,6(X):e28075.
APA	Hu BX.,Li X.,Chen GJ.,Zhang YP.,Fraser NW.,...&Zhang QP.(2016).Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome.SCIENTIFIC REPORTS,6(X),e28075.
MLA	Hu BX,et al."Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome".SCIENTIFIC REPORTS 6.X(2016):e28075.