Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA
	Yao YG 1,2; Kong QP 1,2; Man XY 3; Bandelt HJ 4; Zhang YP[*]1,5
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2003
卷号	20 期号:2 页码:214-219
关键词	mtDNA ancient DNA Han Chinese
通讯作者	zhangyp@public.km.yn.cn.
合作状况	其它
英文摘要	The decipherment of the meager information provided by short fragments of ancient mitochondrial DNA (mtDNA) is notoriously difficult but is regarded as a most promising way toward reconstructing the past from the genetic perspective. By haplogroup-specific hypervariable segment (HVS) motif search and matching or near-matching with available modem data sets, most of the ancient mtDNAs can be tentatively assigned to haplogroups, which are often subcontinent specific. Further typing for mtDNA haplogroup-diagnostic coding region polymorphisms, however, is indispensable for establishing the geographic/genetic affinities of ancient samples with less ambiguity. In the present study, we sequenced a fragment (similar to 982 bp) of the mtDNA control region in 76 Han individuals from Taian, Shandong, China, and we combined these data with previously reported samples from Zibo and Qingdao, Shandong. The reanalysis of two previously published ancient mtDNA population data sets from Linzi (same province) then indicates that the ancient populations had features in common with the modem populations from south China rather than any specific affinity to the European mtDNA pool. Our results highlight that ancient mtDNA data obtained under different sampling schemes and subject to potential contamination can easily create the impression of drastic spatiotemporal changes in the genetic structure of a regional population during the past few thousand years if inappropriate methods of data analysis are employed.
收录类别	SCI
资助信息	This study was supported by grants from Natural Sciences Foundation of Yunnan Province and Natural Sciences Foundation of China (NSFC).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9675]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_分子人类学昆明动物研究所_重大疾病机理的遗传学
作者单位	1.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Graduate School of the Chinese Academy of Sciences, Beijing, China 3.Taishan Medical College, Taian, Shandong, China 4.Fachbereich Mathematik, Universitat Hamburg, Hamburg, Germany 5.Yunnan University, Kunming, China
推荐引用方式 GB/T 7714	Yao YG,Kong QP,Man XY,et al. Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA[J]. MOLECULAR BIOLOGY AND EVOLUTION,2003,20(2):214-219.
APA	Yao YG,Kong QP,Man XY,Bandelt HJ,&Zhang YP[*].(2003).Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA.MOLECULAR BIOLOGY AND EVOLUTION,20(2),214-219.
MLA	Yao YG,et al."Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA".MOLECULAR BIOLOGY AND EVOLUTION 20.2(2003):214-219.