Population variation reveals independent selection towards small body size in Chinese Debao pony

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Population variation reveals independent selection towards small body size in Chinese Debao pony
	Kader A 1; Li Y 2; Dong KZ 1; Irwin DM 3; Zhao QJ 1; He XH 1; Liu JF 4; Pu YB 1; Gorkhali NA 1; Liu XX 1
刊名	GENOME BIOLOGY AND EVOLUTION
	2016
卷号	8 期号:1 页码:42-50
关键词	Association Genetic differentiation Selective signature TBX3 XP-EHH
其他题名	This work was supported by the Agricultural Science and Technology Innovation Program of China (ASTIP- IAS01), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13020600), the National Natural Science Foundation of China (31272403) and the Domestic Animals Sharing Platform in China.
通讯作者	wudongdong@mail.kiz.ac.cn ; mayuehui@caas.cn
合作状况	其它
英文摘要	Body size, one of the most important quantitative traits under evolutionary scrutiny, varies considerably among species and among populations within species. Revealing the genetic basis underlying this variation is very important, particularly in humans where there is a close relationship with diseases and in domestic animals as the selective patterns are associated with improvements in production traits. The Debao pony is a horse breed with small body size that is unique to China; however, it is unknown whether the size-related candidate genes identified in Western breeds also account for the small body size of the Debao pony. Here, we compared individual horses from the Debao population with other two Chinese horse populations using SNPs identified with the Equine SNP 65 Bead Chip. The previously reported size-related candidate gene HMGA2 showed a significant signature for selection, consistent with its role observed in human populations. More interestingly, we found a candidate gene TBX3, which had not been observed in previous studies on horse body size that displayed the highest differentiation and most significant association, and thus likely is the dominating factor for the small stature of the Debao pony. Further comparison between the Debao pony and other breeds of horses from around the world demonstrated that TBX3 was selected independently in the Debao pony, suggesting that there were multiple origins of small stature in the horse.
收录类别	SCI
资助信息	This work was supported by the Agricultural Science and Technology Innovation Program of China (ASTIP- IAS01), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13020600), the National Natural Science Foundation of China (31272403) and the Domestic Animals Sharing Platform in China.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9505]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_进化与发育转录组学
作者单位	1.Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada 4.College of Animal Science and Technology, China Agricultural University, Beijing, China
推荐引用方式 GB/T 7714	Kader A,Li Y,Dong KZ,et al. Population variation reveals independent selection towards small body size in Chinese Debao pony[J]. GENOME BIOLOGY AND EVOLUTION,2016,8(1):42-50.
APA	Kader A.,Li Y.,Dong KZ.,Irwin DM.,Zhao QJ.,...&Ma YH[*].(2016).Population variation reveals independent selection towards small body size in Chinese Debao pony.GENOME BIOLOGY AND EVOLUTION,8(1),42-50.
MLA	Kader A,et al."Population variation reveals independent selection towards small body size in Chinese Debao pony".GENOME BIOLOGY AND EVOLUTION 8.1(2016):42-50.