Lack of association of IL-6 (-174 G > C) and TNF-alpha (-238 G > A) variants with paranoid schizophrenia in Indian Bengalee population

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	Lack of association of IL-6 (-174 G > C) and TNF-alpha (-238 G > A) variants with paranoid schizophrenia in Indian Bengalee population
	Debnath M[*]1; Mitra B 2,4; Bera NK 3; Chaudhuri TK 2; Zhang YP 1,4
刊名	CYTOKINE
	2013
卷号	61 期号:2 页码:455-458
关键词	Paranoid schizophrenia Inflammation IL-6 TNF-alpha
通讯作者	monozeet@gmail.com
合作状况	其它
英文摘要	Schizophrenia is a chronic debilitating neuropsychiatric disorder with complex etiopathology. Growing evidence suggests a significant role of chronic low grade inflammation in the pathophysiology of schizophrenia. Multiple immunological, genetic polymorphism and gene expression studies have established crucial roles of certain pro-inflammatory cytokines in the immune-mediated risk of schizophrenia. Although genetic studies suggest some variants within the pro-inflammatory IL-1 beta, IL-6, and TNF-alpha, genes conferring risk to schizophrenia, the results however have been contradictory in various populations. In the present investigation, promoter SNPs of IL-6 (-174 G > C) and TNF-alpha, (-238 G > A) genes have been studied to evaluate whether these variants contribute to schizophrenia susceptibility in Indian Bengalee population. Genotyping of the above SNPs was done in 100 well characterized and confirmed cases of paranoid schizophrenia and equal number of healthy donors belonging to the same ethnic group by using ABI 3730 Genetic Analyzer. No significant differences in genotype as well as allele frequencies were observed for IL-6 and TNF-alpha variants between the patient and control groups.
收录类别	SCI
语种	英语
WOS记录号	WOS:000314742800020
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7663]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Kunming, China 2.Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, West Bengal, India 3.Department of Psychiatry, North Bengal Medical College and Hospital, Siliguri, West Bengal, India 4.Laboratory for Conservation and Utilization of Bioresources, Yunnan University, Kunming, China
推荐引用方式 GB/T 7714	Debnath M[*],Mitra B,Bera NK,et al. Lack of association of IL-6 (-174 G > C) and TNF-alpha (-238 G > A) variants with paranoid schizophrenia in Indian Bengalee population[J]. CYTOKINE,2013,61(2):455-458.
APA	Debnath M[*],Mitra B,Bera NK,Chaudhuri TK,&Zhang YP.(2013).Lack of association of IL-6 (-174 G > C) and TNF-alpha (-238 G > A) variants with paranoid schizophrenia in Indian Bengalee population.CYTOKINE,61(2),455-458.
MLA	Debnath M[*],et al."Lack of association of IL-6 (-174 G > C) and TNF-alpha (-238 G > A) variants with paranoid schizophrenia in Indian Bengalee population".CYTOKINE 61.2(2013):455-458.