Adaptive Evolution of the Hox Gene Family for Development in Bats and Dolphins

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Adaptive Evolution of the Hox Gene Family for Development in Bats and Dolphins
	Liang L 1,3; Shen YY[]1,2; Pan XW 4; Zhou TC 4; Yang C 4; Irwin DM 1,5,6; Zhang YP[]1,4
刊名	PLOS ONE
	2013
卷号	8 期号:6 页码:e65944
通讯作者	shenyy@xmu.edu.cn ; zhangyp@mail.kiz.ac.cn
合作状况	其它
英文摘要	Bats and cetaceans (i.e., whales, dolphins, porpoises) are two kinds of mammals with unique locomotive styles and occupy novel niches. Bats are the only mammals capable of sustained flight in the sky, while cetaceans have returned to the aquatic environment and are specialized for swimming. Associated with these novel adaptations to their environment, various development changes have occurred to their body plans and associated structures. Given the importance of Hox genes in many aspects of embryonic development, we conducted an analysis of the coding regions of all Hox gene family members from bats (represented by Pteropus vampyrus, Pteropus alecto, Myotis lucifugus and Myotis davidii) and cetaceans (represented by Tursiops truncatus) for adaptive evolution using the available draft genome sequences. Differences in the selective pressures acting on many Hox genes in bats and cetaceans were found compared to other mammals. Positive selection, however, was not found to act on any of the Hox genes in the common ancestor of bats and only upon Hoxb9 in cetaceans. PCR amplification data from additional bat and cetacean species, and application of the branch-site test 2, showed that the Hoxb2 gene within bats had significant evidence of positive selection. Thus, our study, with genomic and newly sequenced Hox genes, identifies two candidate Hox genes that may be closely linked with developmental changes in bats and cetaceans, such as those associated with the pancreatic, neuronal, thymus shape and forelimb. In addition, the difference in our results from the genome-wide scan and newly sequenced data reveals that great care must be taken in interpreting results from draft genome data from a limited number of species, and deep genetic sampling of a particular clade is a powerful tool for generating complementary data to address this limitation.
收录类别	SCI
资助信息	This work was supported by the National Basic Research Program of China to Y-PZ (973 Program, 2007CB411600), National Natural Science Foundation of China (30621092 and 31172080), Key Program of West Light Foundation of the Chinese Academy of Sciences to YYS (Y102281081), and Bureau of Science and Technology of Yunnan Province.
语种	英语
WOS记录号	WOS:000321223000007
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7604]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China 3.Graduate School of the Chinese Academy of Sciences, Beijing, China 4.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China 5.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada 6.Banting and Best Diabetes Centre, University of Toronto, Toronto, ON, Canada
推荐引用方式 GB/T 7714	Liang L,Shen YY[*],Pan XW,et al. Adaptive Evolution of the Hox Gene Family for Development in Bats and Dolphins[J]. PLOS ONE,2013,8(6):e65944.
APA	Liang L.,Shen YY[].,Pan XW.,Zhou TC.,Yang C.,...&Zhang YP[].(2013).Adaptive Evolution of the Hox Gene Family for Development in Bats and Dolphins.PLOS ONE,8(6),e65944.
MLA	Liang L,et al."Adaptive Evolution of the Hox Gene Family for Development in Bats and Dolphins".PLOS ONE 8.6(2013):e65944.