Stepwise loss of motilin and its specific receptor genes in rodents

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	Stepwise loss of motilin and its specific receptor genes in rodents
	He J 1; Irwin DM 2; Chen R 1,3; Zhang YP[*]1,4
刊名	JOURNAL OF MOLECULAR ENDOCRINOLOGY
	2010
卷号	44 期号:1 页码:37-44
ISSN号	0952-5041
通讯作者	zhangyp@mail.kiz.ac.cn or zhangyp1@263.net.cn
合作状况	其它
英文摘要	Specific interactions among biomolecules drive virtually all cellular functions and underlie phenotypic complexity and diversity. Biomolecules are not isolated particles, but are elements of integrated interaction networks, and play their roles through specific interactions. Simultaneous emergence or loss of multiple interacting partners is unlikely. If one of the interacting partners is lost, then what are the evolutionary consequences for the retained partner? Taking advantages of the availability of the large number of mammalian genome sequences and knowledge of phylogenetic relationships of the species, we examined the evolutionary fate of the motilin (MLN) hormone gene, after the pseudogenization of its specific receptor, MLN receptor (MLNR), on the rodent lineage. We speculate that the MLNR gene became a pseudogene before the divergence of the squirrel and other rodents about 75 mya. The evolutionary consequences for the MLN gene were diverse. While an intact open reading frame for the MLN gene, which appears functional, was preserved in the kangaroo rat, the MLN gene became inactivated independently on the lineages leading to the guinea pig and the common ancestor of the mouse and rat. Gain and loss of specific interactions among biomolecules through the birth and death of genes for biomolecules point to a general evolutionary dynamic: gene birth and death are widespread phenomena in genome evolution, at the genetic level; thus, once mutations arise, a stepwise process of elaboration and optimization ensues, which gradually integrates and orders mutations into a coherent pattern.
收录类别	SCI
资助信息	This work was supported by grants from the National Basic Research Program of China (973 Program, 2007CB411600), the National Natural Science Foundation of China (30621092, 30623007), and Bureau of Science and Technology of Yunnan Province.
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4379]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, People’s Republic of China 2.Department of Laboratory Medicine and Pathobiology and Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada 3.The Graduate School, Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 4.Laboratory for Conservation and Utilization of Bioresource, Yunnan University, Kunming 650091, People’s Republic of China
推荐引用方式 GB/T 7714	He J,Irwin DM,Chen R,et al. Stepwise loss of motilin and its specific receptor genes in rodents[J]. JOURNAL OF MOLECULAR ENDOCRINOLOGY,2010,44(1):37-44.
APA	He J,Irwin DM,Chen R,&Zhang YP[*].(2010).Stepwise loss of motilin and its specific receptor genes in rodents.JOURNAL OF MOLECULAR ENDOCRINOLOGY,44(1),37-44.
MLA	He J,et al."Stepwise loss of motilin and its specific receptor genes in rodents".JOURNAL OF MOLECULAR ENDOCRINOLOGY 44.1(2010):37-44.