Pseudogenization of the tumor-growth promoter angiogenin in a leaf-eating monkey

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	Pseudogenization of the tumor-growth promoter angiogenin in a leaf-eating monkey
	Zhang JZ[*]1; Zhang YP 2
刊名	GENE
	2003
卷号	308 期号:X 页码:95-101
关键词	seudogene colobine primate ribonuclease douc langur
ISSN号	0378-1119
通讯作者	jianzhi@umich.edu
合作状况	其它
英文摘要	Physiological functions of human genes may be studied by gene-knockout experiments in model organisms such as the mouse. This strategy relies on the existence of one-to-one gene orthology between the human and mouse. When lineage-specific gene duplication occurs and paralogous genes share a certain degree of functional redundancy, knockout mice may not provide accurate functional information on human genes. Angiogenin is a small protein that stimulates blood-vessel growth and promotes tumor development. Humans and related primates only have one angiogenin gene, while mice have three paralogous genes. This makes it difficult to generate angiogenin-knockout mice and even more difficult to interpret the genotype-phenotype relation from such animals should they be generated. We here show that in the douc langur (Pygathrix nemaeus), an Asian leaf-eating colobine monkey, the single-copy angiogenin gene has a one-nucleotide deletion in the sixth codon of the mature peptide, generating a premature stop codon. This nucleotide deletion is found in five unrelated individuals sequenced, and therefore is likely to have been fixed in the species. Five colobine species that are closely related to the douc langur have intact angiogenin genes, suggesting that the pseudogenization event was recent and unique to the douc langur lineage. This natural knockout experiment suggests that primate angiogenin is dispensable even in the wild. Further physiological studies of douc largurs may offer additional information on the role of this cancer-related gene in normal physiology of primates, including humans. Our findings also provide a strong case for the importance of evolutionary analysis in biomedical studies of gene functions.
收录类别	SCI
资助信息	This work was supported by a startup fund from the University of Michigan to J.Z. and research grants from the National Institutes of Health (R01- GM67030) to J.Z., Natural Science Foundation of China to Y.P.Z., and Chinese Academy of Sciences (KSCX2-1-05) to Y.P.Z.
原文出处	200330895.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4093]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_细胞与分子进化开放实验室
作者单位	1.Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Sciences Building, 830 North University Avenue, Ann Arbor, MI 48109, USA 2.Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Zhang JZ[*],Zhang YP. Pseudogenization of the tumor-growth promoter angiogenin in a leaf-eating monkey[J]. GENE,2003,308(X):95-101.
APA	Zhang JZ[*],&Zhang YP.(2003).Pseudogenization of the tumor-growth promoter angiogenin in a leaf-eating monkey.GENE,308(X),95-101.
MLA	Zhang JZ[*],et al."Pseudogenization of the tumor-growth promoter angiogenin in a leaf-eating monkey".GENE 308.X(2003):95-101.