Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study

	Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study
	Shen T 1; Li CC[1]1; Wang B 1; Yang WM 1; Zhang C 2; Wu ZG 1; Qiu MH 1; Liu J 3; Xu YF[]1,4; Peng DH[]1
刊名	PSYCHIATRY INVESTIGATION
	2015
卷号	12 期号:2 页码:227-234
关键词	Depression First episode Cognition connectivity network Functional magnetic resonance imaging Resting state
通讯作者	hyyyyb@gmail.com ; pdhsh@126.com
合作状况	其它
英文摘要	Objective Evidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain. Methods Sixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps. Results The CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls. Conclusion There are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms-of cognitive dysfunction in MDD.
收录类别	SCI
语种	英语
公开日期	2015-06-08
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8339]
专题	昆明动物研究所_分子病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China 3.Department of Medical Imaging, Shanghai Fifth People’s Hospital, Shanghai, China 4.Huashan Hospital, Fudan University, Shanghai, China
推荐引用方式 GB/T 7714	Shen T,Li CC[1],Wang B,et al. Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study[J]. PSYCHIATRY INVESTIGATION,2015,12(2):227-234.
APA	Shen T.,Li CC[1].,Wang B.,Yang WM.,Zhang C.,...&Peng DH[*].(2015).Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study.PSYCHIATRY INVESTIGATION,12(2),227-234.
MLA	Shen T,et al."Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study".PSYCHIATRY INVESTIGATION 12.2(2015):227-234.