Identification of ANKK1 rs1800497 Variant in Schizophrenia: New Data and Meta-Analysis

	Identification of ANKK1 rs1800497 Variant in Schizophrenia: New Data and Meta-Analysis
	Zhang C 1,2; Zhang JT 3; Fan J 4; Cheng WH 4; Du YS 4; Yu SY[]5; Fang YR[]6
刊名	AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
	2014
卷号	165 期号:7 页码:564-571
关键词	Meta-analysis Age at onset Polymorphism ANKK1 Schizophrenia
通讯作者	yushuny@yahoo.com ; yirufang@aliyun.com
英文摘要	One functional polymorphism (rs1800497) within the ankyrin repeat and kinase domain containing-1 gene (ANKK1) was reported to be associated with schizophrenia, but results among different studies vary and conclusions remain controversial. The present study sought to clarify this potential association among a population of Han Chinese with early onset schizophrenia using a case-control (396 patients and 399 controls) and family based study (103 trios). We then performed a meta-analysis (comprising 11 case-control and 2 family-based studies) based on the present literature. Results of the association study revealed no significant difference in allele and genotype frequencies between the cases and controls, and no significant transmission distortion was detected. Kaplan-Meier survival analysis showed that age at onset in schizophrenia was significantly associated with the rs1800497 polymorphism in female patients, but not in males. Female T allele carriers had a lower age at onset than those without T allele (log rank statistic (2)=5.16, P=0.023; corrected P=0.046). Meta-analysis results indicated that rs1800497 is not associated with schizophrenia in the overall population (P=0.77 for the case-control studies; P=0.06 for the family-based studies). Our results support the hypothesis that rs1800497 polymorphism is likely to have a modifying rather than causative effect on schizophrenia. These findings may represent a significant genetic clue for the etiology of schizophrenia in females, but further investigation is required to clarify the exact role of ANKK1 in the development of schizophrenia.
收录类别	SCI
资助信息	This work was supported by the National Natural Science Foundation of China (81000581), the China Postdoctoral Science Foundation (2013M530410),theShanghaiScience&TechnologyDevelopment Foundation (12140904200) and the National Key Clinical Disci- plines at Shanghai Mental Health Center (OMA-MH, 2011-873).
语种	英语
WOS记录号	WOS:000341979000003
公开日期	2014-10-15
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8043]
专题	昆明动物研究所_分子病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 3.Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China 4.Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 5.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 6.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
推荐引用方式 GB/T 7714	Zhang C,Zhang JT,Fan J,et al. Identification of ANKK1 rs1800497 Variant in Schizophrenia: New Data and Meta-Analysis[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2014,165(7):564-571.
APA	Zhang C.,Zhang JT.,Fan J.,Cheng WH.,Du YS.,...&Fang YR[*].(2014).Identification of ANKK1 rs1800497 Variant in Schizophrenia: New Data and Meta-Analysis.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,165(7),564-571.
MLA	Zhang C,et al."Identification of ANKK1 rs1800497 Variant in Schizophrenia: New Data and Meta-Analysis".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 165.7(2014):564-571.