Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia

	Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia
	Zhang C 1,2; Cai J 1; Zhang JT 3; Li ZZ 4; Guo ZW 3; Zhang XM[1,6]5; Lu WH 1; Zhang Y 1; Yuan AH 6; Yu SY[*]6
刊名	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
	2014
卷号	50 期号:X 页码:110-115
关键词	ANK3 First-episode schizophrenia SNP Working memory
通讯作者	yushuny@yahoo.com ; yirufang@aliyun.com
合作状况	其它
英文摘要	Neuropsychological endophenotype approach is an emerging strategy in schizophrenia research to understand and identify the functional importance of genetically transmitted, brain-based deficits present in this disorder. Accumulating evidence indicated that working memory deficit is a core neuropsychological dysfunction in schizophrenia and a primary endophenotype indexing the liability to develop schizophrenia. Genetic variation in ankyrin 3 gene (ANK3) is likely to have widespread cognitive effects. Our previous study has identified a significant association of ANK3 SNPs and schizophrenia. In this study, we aimed to examine whether the schizophrenia-risk SNPs within ANK3 may affect working memory deficits in schizophrenia patients. Herein, we assess the working memory performance in 163 patients with first-episode, antipsychotic-naive schizophrenia and 42 sex, age-matched healthy subjects using N-back task. Two SNPs rs10761482 and rs10994336 were genotyped among the patients and 209 controls. Our results showed that schizophrenia patients showed significantly poorer performance than healthy controls on N-back task (ps < 0.01). After adjusting for the scores of intelligence quotient, memory quotient and the demographic factors, there was a significant genotype effect of the rs10994336 on the accuracy rate and reaction time of 2-back item (p = 0.048 and 0.024, respectively). Post-hoc analyses showed that patients with rs10994336T/T genotype had significantly lower accuracy rate and more reaction time at 2back task than those with T/C and C/C genotypes. The association of SNP rs10994336 with schizophrenia was replicated in our sample (genotypic p = 0.024 and allelic p = 0.006). However, we did not find any significant association of rs10761482 with schizophrenia and parameters in N-back task. Our results indicated that genetic variation within ANK3 may exert gene-specific modulating effects on working memory deficits in schizophrenia.
收录类别	SCI
资助信息	This work was supported by the National Natural Science Foundation of China (81000581), the China Postdoctoral Science Foundation (2013M530410), the Shanghai Science & Technology Development Foundation (12140904200) and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH, 2011–873).
语种	英语
WOS记录号	WOS:000330574000013
公开日期	2014-03-07
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7813]
专题	昆明动物研究所_分子病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 3.Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China 4.Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China 5.Department of Psychiatry, Tongji Hospital, Tongji University School of Medicine, Shanghai, China 6.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 7.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
推荐引用方式 GB/T 7714	Zhang C,Cai J,Zhang JT,et al. Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2014,50(X):110-115.
APA	Zhang C.,Cai J.,Zhang JT.,Li ZZ.,Guo ZW.,...&Fang YR[*].(2014).Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,50(X),110-115.
MLA	Zhang C,et al."Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 50.X(2014):110-115.