Transcriptome analysis of different developmental stages of amphioxus reveals dynamic changes of distinct classes of genes during development.

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 发育生物学

	Transcriptome analysis of different developmental stages of amphioxus reveals dynamic changes of distinct classes of genes during development.
	Yang KY 1,2; Chen Y 3; Zhang YF 1; Liu MH 1,2; Chen JY 5; Mao BY[]4; Tsui SK[]1,2; Zhang ZG 4; Ng PK 1; Zhou WJ 1
刊名	SCIENTIFIC REPORTS
	2016
卷号	6 期号:X 页码:e23195
通讯作者	mao@mail.kiz.ac.cn ; kwtsui@cuhk.edu.hk
合作状况	其它
英文摘要	Vertebrates diverged from other chordates approximately 500 million years ago and have adopted several modifications of developmental processes. Amphioxus is widely used in evolutionary developmental biology research, such as on the basic patterning mechanisms involved in the chordate body plan and the origin of vertebrates. The fast development of next-generation sequencing has advanced knowledge of the genomic organization of amphioxus; however, many aspects of gene regulation during amphioxus development have not been fully characterized. In this study, we applied high-throughput sequencing on the transcriptomes of 13 developmental stages of Chinese amphioxus to gain a comprehensive understanding of transcriptional processes occurring from the fertilized egg to the adult stage. The expression levels of 3,423 genes were significantly changed (FDR ≤ 0.01). All of these genes were included in a clustering analysis, and enrichment of biological functions associated with these clusters was determined. Significant changes were observed in several important processes, including the down-regulation of the cell cycle and the up-regulation of translation. These results should build a foundation for identifying developmentally important genes, especially those regulatory factors involved in amphioxus development, and advance understanding of the developmental dynamics in vertebrates.
收录类别	SCI
资助信息	This work was supported by the General Research Fund from the Hong Kong Research Grants Council (reference number: CUHK 4647/10M). This work was also supported by a Key project from the National Natural Science Foundation of China (31123005) and Innovation Project of Chinese Academy of Sciences (KSCX2-EW-J-23) to B.M.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9579]
专题	昆明动物研究所_发育生物学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China 2.Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong SAR, China 3.Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 5.Nanjing Institute of Paleontology and Geology, Chinese Academy of Sciences, Nanjing, China
推荐引用方式 GB/T 7714	Yang KY,Chen Y,Zhang YF,et al. Transcriptome analysis of different developmental stages of amphioxus reveals dynamic changes of distinct classes of genes during development.[J]. SCIENTIFIC REPORTS,2016,6(X):e23195.
APA	Yang KY.,Chen Y.,Zhang YF.,Liu MH.,Chen JY.,...&Zhou WJ.(2016).Transcriptome analysis of different developmental stages of amphioxus reveals dynamic changes of distinct classes of genes during development..SCIENTIFIC REPORTS,6(X),e23195.
MLA	Yang KY,et al."Transcriptome analysis of different developmental stages of amphioxus reveals dynamic changes of distinct classes of genes during development.".SCIENTIFIC REPORTS 6.X(2016):e23195.