Planarian myosin essential light chain is involved in the formation of brain lateral branches during regeneration

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	Planarian myosin essential light chain is involved in the formation of brain lateral branches during regeneration
	Yu SY 1; Chen XH 1; Mao BY 2; Zhao BS[*]1; Yuan ZQ 1; Zhou LM 1; Pang QX 1
刊名	MOLECULAR GENETICS AND GENOMICS
	2015
卷号	290 期号:4 页码:1277-1285
关键词	DjElc Embryo Regeneration Central nervous system Planarian
通讯作者	zhaobosheng@sdut.edu.cn
合作状况	其它
英文摘要	The myosin essential light chain (ELC) is a structure component of the actomyosin cross-bridge, however, the functions in the central nervous system (CNS) development and regeneration remain poorly understood. Planarian Dugesia japonica has revealed fundamental mechanisms and unique aspects of neuroscience and neuroregeneration. In this study, the cDNA DjElc, encoding a planarian essential light chain of myosin, was identified from the planarian Dugesia japonica cDNA library. It encodes a deduced protein with highly conserved functionally domains EF-Hand and Ca2+ binding sites that shares significant similarity with other members of ELC. Whole mount in situ hybridization studies show that DjElc expressed in CNS during embryonic development and regeneration of adult planarians. Loss of function of DjElc by RNA interference during planarian regeneration inhibits brain lateral branches regeneration completely. In conclusion, these results demonstrated that DjElc is required for maintenance of neurons and neurite outgrowth, particularly for involving the brain later branch regeneration.
收录类别	SCI
资助信息	This work was supported by grants from Shan- dong Province Natural Science Foundation of China (ZR2013CM011) and State Key Laboratory of Genetic Resource and Evolution, Kun- ming Institute of Zoology, Chinese Academy of Sciences (GREKF09- 04) and a Project of Shandong Province Higher Educational Science and Technology Program, China (J11LC09).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9230]
专题	昆明动物研究所_发育生物学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Laboratory of Developmental and Evolutionary Biology, School of Life Sciences, Shandong University of Technology, 12 Zhangzhou Road, Zibo 255049, People’s Republic of China 2.State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Kunming 650223, People’s Republic of China
推荐引用方式 GB/T 7714	Yu SY,Chen XH,Mao BY,et al. Planarian myosin essential light chain is involved in the formation of brain lateral branches during regeneration[J]. MOLECULAR GENETICS AND GENOMICS,2015,290(4):1277-1285.
APA	Yu SY.,Chen XH.,Mao BY.,Zhao BS[*].,Yuan ZQ.,...&Pang QX.(2015).Planarian myosin essential light chain is involved in the formation of brain lateral branches during regeneration.MOLECULAR GENETICS AND GENOMICS,290(4),1277-1285.
MLA	Yu SY,et al."Planarian myosin essential light chain is involved in the formation of brain lateral branches during regeneration".MOLECULAR GENETICS AND GENOMICS 290.4(2015):1277-1285.