Novel peptides from skins of amphibians showed broad-spectrum antimicrobial activities

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物活性蛋白多肽组学

	Novel peptides from skins of amphibians showed broad-spectrum antimicrobial activities
	Wang YM 1; Zhang Y 2,3; Lee WH 3; Yang XW[]4; Zhang Y[]3
刊名	CHEMICAL BIOLOGY & DRUG DESIGN
	2016
卷号	87 期号:3 页码:419-424
关键词	Amphibian Antimicrobial peptides Skins
通讯作者	yangxinwanghp@163.com ; zhangy@mail.kiz.ac.cn
合作状况	其它
英文摘要	Peptide agents are often considered as potential biomaterials for developing new drugs that can overcome the rising resistance of pathogenic microorganisms to classic antibiotic treatments. One key source of peptide agents is amphibian skin, since they provide a great deal of naturally occurring antimicrobial peptide (AMP) templates awaiting further exploitation and utilization. In the present study, 12 novel AMPs from the skins of 3 ranid frogs, Rana limnocharis, R. exilispinosa and Amolops afghanus were identified by using a 5'PCR primer. 11 AMPs exhibited similarities with currently known AMP families, including Brevinin-1 and -2, Esculentin-1 and Nigrocin; besides, one AMP, named as Limnochariin, represented a novel AMP family. All 12 AMPs contain a C-terminus cyclic motif and most of them show obvious antimicrobial activities against 18 standard and clinically isolated strains of bacteria, including 4 gram-positive bacteria, 11 gram-negative bacteria and 3 fungus. These findings provide helpful insight that will be useful in the design of anti-infective peptide agents.
收录类别	SCI
资助信息	This work was supported by grants from the Chinese National Natural Science Foundation (U1132601, 31270835, 31572268, 31460571), the Key Research Pro- gram of the Chinese Academy of Sciences (KJZD-EW- L03), the Youth Science Foundation of Yunnan Minzu University (2013QN24), the Scientific Research Foundation of Yunnan Minzu University (2014RC005), and the Open Research Fund of Key Laboratory of Chemistry in Ethnic Medicinal Resources (Yunnan Minzu University), State Eth- nic Affairs Commission & Ministry of Education, P.R. China (MZY1403).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9440]
专题	昆明动物研究所_动物活性蛋白多肽组学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Chemistry in Ethnic Medicine Resource, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, 650500, China 2.University of the Chinese Academy of Sciences, Beijing, 100049, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 4.Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China
推荐引用方式 GB/T 7714	Wang YM,Zhang Y,Lee WH,et al. Novel peptides from skins of amphibians showed broad-spectrum antimicrobial activities[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2016,87(3):419-424.
APA	Wang YM,Zhang Y,Lee WH,Yang XW[],&Zhang Y[].(2016).Novel peptides from skins of amphibians showed broad-spectrum antimicrobial activities.CHEMICAL BIOLOGY & DRUG DESIGN,87(3),419-424.
MLA	Wang YM,et al."Novel peptides from skins of amphibians showed broad-spectrum antimicrobial activities".CHEMICAL BIOLOGY & DRUG DESIGN 87.3(2016):419-424.