Antimicrobial peptides from the venom gland of the social wasp Vespa tropica

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物活性蛋白多肽组学

	Antimicrobial peptides from the venom gland of the social wasp Vespa tropica
	Yang XW 1,2; Wang Y 3; Lee WH 1; Zhang Y[*]1
刊名	TOXICON
	2013
卷号	74 期号:X 页码:151-157
关键词	Vespa tropica Venom gland Antimicrobial peptides Mastoparan Chemotactic peptides
通讯作者	zhangy@mail.kiz.ac.cn
英文摘要	Peptide agents are regarded as potential candidates for overcoming the life-threatening resistance of pathogenic microorganisms to classic antibiotics. Accordingly, a peptidomic and genomic investigation of natural antimicrobial peptides (AMPs) can provide structure-functional information for designing peptide antibiotics with therapeutic potential. In the present study, we identified nine AMPs from the venom gland of the wasp Vespa tropica using combined methods of peptidomics and genomics. These AMPs were classified into two different families based on sequence similarity, mastoparan and vespid chemotactic peptides (VCPs), and thus named mastoparan-VT1 to -VT7, VCP-'VT1 and -VT2. Among these nine AMPs, mastoparan-VT1 and VCP-VT1 are identical to peptides from other wasps. These AMPs exerted broad-spectrum antimicrobial activity against standard and clinically isolated strains of bacteria. In addition, they showed weak hemolytic activity toward human erythrocytes. Our results reveal that identical AMPs are widely distributed in different wasp venoms and might provide templates for the development of novel peptide antibiotics
收录类别	SCI
资助信息	This work was supported by grants from the Chinese National Natural Science Foundation (U1132601, 31270835), the Key Research Program of the Chinese Academy of Sciences (KJZD-EW-L03), and the National Basic Research Program of China (973 Program, 2010CB529800).
语种	英语
WOS记录号	WOS:000326005400018
公开日期	2013-11-25
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7708]
专题	昆明动物研究所_动物活性蛋白多肽组学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 East Jiaochang Road, Kunming 650223, Yunnan, China 2.The University of the Chinese Academy of Sciences, Beijing 100049, China 3.Ethic Drug Screening & Pharmacology Center, Key Laboratory of Chemistry in Ethnic Medicine Resource, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650500, China
推荐引用方式 GB/T 7714	Yang XW,Wang Y,Lee WH,et al. Antimicrobial peptides from the venom gland of the social wasp Vespa tropica[J]. TOXICON,2013,74(X):151-157.
APA	Yang XW,Wang Y,Lee WH,&Zhang Y[*].(2013).Antimicrobial peptides from the venom gland of the social wasp Vespa tropica.TOXICON,74(X),151-157.
MLA	Yang XW,et al."Antimicrobial peptides from the venom gland of the social wasp Vespa tropica".TOXICON 74.X(2013):151-157.