A potential wound healing-promoting peptide from frog skin

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物毒素室

	A potential wound healing-promoting peptide from frog skin
	Liu H 1,5; Mu LX 1,5; Tang J 1,5; Shen CB 1,5; Gao C 4; Rong MQ 1; Zhang ZY 1,5; Liu J 1,5; Wu XY 3; Yu HN[*]2
刊名	INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
	2014
卷号	49 期号:X 页码:32-41
关键词	Amphibian Transforming growth factor beta Antimicrobial peptide Wound repair
通讯作者	joannyu@live.cn ; rlai@mail.kiz.ac.cn
英文摘要	Cutaneous wound healing is a dynamic, complex, and well-organized process that requires the orchestration of many different cell types and cellular processes. Transforming growth factor beta 1 is an important factor that plays a key role during wound healing. Amphibian skin has been proven to possess excellent wound healing ability, whilst no bioactive substrate related to it has ever been identified. Here, a potential wound healing-promoting peptide (AH90, ATAWDFGPHGLLPIRPIRIRPLCG) was identified from the frog skin of Odorrana grahami. It showed potential wound healing-promoting activity in a murine model with full thickness dermal wound. AH90 promoted release of transforming growth factor beta 1 through activation of nuclear factor-kappa B and c-Jun NH2-terminal kinase mitogen-activated protein kinases signaling pathways, while inhibitors of nuclear factor-kappa B and c-Jun NH2-terminal kinase inhibited the process. In addition, the effects of AH90 on Smads family proteins, key regulators in transforming growth factor beta 1 signaling pathways, could also be inhibited by transforming growth factor beta 1 antibody. Altogether, this indicated that AH90 promoted wound healing by inducing the release of transforming growth factor beta 1. This current study may facilitate the understanding of effective factors involved in the wound repair of amphibians and the underlying mechanisms as well. Considering its favorable traits as a small peptide that greatly promoting generation of endogenous wound healing agents (transforming growth factor beta 1) without mitogenic effects, AH90 might be an excellent template for the future development of novel wound-healing agents.
收录类别	SCI
资助信息	This work was supported by Ministry of Science and Technology (2010CB529800, 2013CB911300), National Natural Science Foundation (30830021, 31025025, 31070701, 31000960, 31025025, U1132601, 31200590), and Yunnan Province (2011CI139, 2012BC009).
语种	英语
WOS记录号	WOS:000333854400005
公开日期	2014-06-04
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7863]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 2.Institute of Marine Biological Technology, School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning, China 3.Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA 4.College of Veterinary Medicine of Jiangsu Animal Husbandry & Veterinary College, Taizhou 225300, Jiangsu, China 5.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式 GB/T 7714	Liu H,Mu LX,Tang J,et al. A potential wound healing-promoting peptide from frog skin[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2014,49(X):32-41.
APA	Liu H.,Mu LX.,Tang J.,Shen CB.,Gao C.,...&Lai R[*].(2014).A potential wound healing-promoting peptide from frog skin.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,49(X),32-41.
MLA	Liu H,et al."A potential wound healing-promoting peptide from frog skin".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 49.X(2014):32-41.