A Small Peptide with Potential Ability to Promote Wound Healing

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	A Small Peptide with Potential Ability to Promote Wound Healing
	Tang J 1,4; Liu H 1,4; Gao C 3; Mu LX 1,4; Yang SL 1,4; Rong MQ 1; Zhang ZY 1,4; Liu J 1,4; Ding Q[]2; Lai R[]1
刊名	PLOS ONE
	2014
卷号	9 期号:3 页码:e92082
通讯作者	dqnj2000@aliyun.com ; rlai@mail.kiz.ac.cn
英文摘要	Wound-healing represents a major health burden, such as diabetes-induced skin ulcers and burning. Many works are being tried to find ideal clinical wound-healing biomaterials. Especially, small molecules with low cost and function to promote production of endogenous wound healing agents (i.e. transforming growth factor beta, TGF-beta) are excellent candidates. In this study, a small peptide (tiger17, c[WCKPKPKPRCH-NH2]) containing only 11 amino acid residues was designed and proved to be a potent wound healer. It showed strong wound healing-promoting activity in a murine model of full thickness dermal wound. Tiger17 exerted significant effects on three stages of wound healing progresses including (1) the induction of macrophages recruitment to wound site at inflammatory reaction stage; (2) the promotion of the migration and proliferation both keratinocytes and fibroblasts, leading to reepithelialization and granulation tissue formation; and (3) tissue remodeling phase, by promoting the release of transforming TGF-beta 1 and interleukin 6 (IL-6) in murine macrophages and activating mitogen-activated protein kinases (MAPK) signaling pathways. Considering its easy production, store and transfer and function to promote production of endogenous wound healing agents (TGF-beta), tiger17 might be an exciting biomaterial or template for the development of novel wound-healing agents.
资助信息	This work was supported by Ministry of Science and Technology (2010CB529800, 2013CB911300), National Natural Science Foundation (30830021, 31025025, 31070701, 31000960, 31025025, U1132601, 31200590), and Yunnan Province (2011CI139, 2012BC009)
语种	英语
WOS记录号	WOS:000333348500081
公开日期	2014-06-03
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7855]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Department of Breast Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China 3.College of Veterinary Medicine of Jiangsu Animal Husbandry and Veterinary College, Taizhou, Jiangsu, China 4.Graduate University of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Tang J,Liu H,Gao C,et al. A Small Peptide with Potential Ability to Promote Wound Healing[J]. PLOS ONE,2014,9(3):e92082.
APA	Tang J.,Liu H.,Gao C.,Mu LX.,Yang SL.,...&Lai R[*].(2014).A Small Peptide with Potential Ability to Promote Wound Healing.PLOS ONE,9(3),e92082.
MLA	Tang J,et al."A Small Peptide with Potential Ability to Promote Wound Healing".PLOS ONE 9.3(2014):e92082.