Purification, characterization and cloning of two novel tigerinin-like peptides from skin secretions of Fejervarya cancrivora | |
Song YZ1,4; Lu Y2; Wang LJ3; Yang HL1,4; Zhang KY2; Lai R[*]1,2 | |
刊名 | PEPTIDES |
2009 | |
卷号 | 30期号:7页码:1228-1232 |
关键词 | Amphibian Antimicrobial peptide Fejervarya cancrivora Brackish water Tigerinin |
ISSN号 | 0196-9781 |
通讯作者 | rlai@mail.kiz.ac.cn |
合作状况 | 其它 |
英文摘要 | While investigating the innate defense of brackish water-living amphibian and its comparison with freshwater-living amphibians, two novel 12-residue antimicrobial peptides were purified from the skin secretions of the crab-eating frog, Fejervarya cancrivora which typically inhabits brackish water of mangrove forests of Southeast Asia. These two antimicrobial peptides, tigerinin-RC1 and -RC2 share significant structural similarity with tigerinins found in the skin of Indian frog, Hoplobatrachus tigerinus. cDNAs encoding tigerinin-RC1 and -RC2 were also cloned from the skin cDNA library of F. cancrivora. Tigerinin-RC precursors are composed of 71 amino acid residues including a signal peptide, acidic spacer peptide, which are very similar to other amphibian antimicrobial peptide precursors and mature tigerinin-RC. The current results confirmed that both amphibians inhabiting freshwater and brackish water share the same antimicrobial peptide family to exert innate defense. Furthermore, the current work was also the first report of precursor and cDNA cloning of the tigerinin antimicrobial peptide family. |
收录类别 | SCI |
资助信息 | This work was supported by the Chinese National Natural Science Foundation (30830021), Chinese Academy of Sciences (KSCXZ-YW-R-088, KSCX2-YW-G-024), and the Ministry of Science (2008AA02Z133, 2008AA101001). |
语种 | 英语 |
公开日期 | 2010-08-24 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.42:8088/handle/152453/2559] |
专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
作者单位 | 1.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 3.College of Life Sciences, Hainan Normal University, Haikou 650223, Hainan, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China |
推荐引用方式 GB/T 7714 | Song YZ,Lu Y,Wang LJ,et al. Purification, characterization and cloning of two novel tigerinin-like peptides from skin secretions of Fejervarya cancrivora[J]. PEPTIDES,2009,30(7):1228-1232. |
APA | Song YZ,Lu Y,Wang LJ,Yang HL,Zhang KY,&Lai R[*].(2009).Purification, characterization and cloning of two novel tigerinin-like peptides from skin secretions of Fejervarya cancrivora.PEPTIDES,30(7),1228-1232. |
MLA | Song YZ,et al."Purification, characterization and cloning of two novel tigerinin-like peptides from skin secretions of Fejervarya cancrivora".PEPTIDES 30.7(2009):1228-1232. |
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